eISSN 2329-0358


Welcome to the Annals of Transplantation

Dr. Thomas E. Starzl, "father of organ transplantation", dies at 90
Thomas E. Starzl, MD, PhD, died peacefully Saturday, March 4, 2017, at his home in Pittsburgh. He was born March 11, 1926, in LeMars, Iowa, the second son of Roman Frederick Starzl and Anna Laura (nee Fitzgerald) Starzl. His parents were the first generation American offspring of Czechoslovakian and Irish immigrants.
This... read more

Published: 2017-03-21

Relationships Between Clinical, Self-Reported, and Donation Specific Outcomes: A Prospective Follow-up Study 10 Years After Kidney Donation

Käthe B. Meyer, Anders Hartmann, Geir Mjøen, Marit H. Andersen

(Department of Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway)

Ann Transplant 2017; 22:148-155

DOI: 10.12659/AOT.902330

BACKGROUND: Long-term consequences of donor nephrectomy might be reduced kidney function, increased risk for cardiovascular disease, impaired quality of life, and fatigue. Few studies have investigated associations between clinical and self-reported outcomes in a long-term perspective. Thus, we aimed to investigate relationships between clinical, self-reported, and donation-specific outcomes in a nationwide cohort.
MATERIAL AND METHODS: We conducted a prospective follow-up study and assessed pre- and post-donation data from 202 donors who donated in 2001–2004. During 2012–2013, data on donors’ self-reported (quality of life and fatigue) and donor-specific outcomes were collected. We performed linear regression for each component score of the generic instrument Short-Form, SF36v2, measuring quality of life, and the 5 domains of fatigue. Clinical parameters tested as independent variables were medical treatment of hyperlipidemia or hypertension, current smoking status, BMI, hemoglobin, and eGFR. Data were adjusted for age and gender.
RESULTS: Approximately 10 years after donation, 67 donors were hypertensive and 54 donors had eGFR <60 ml/min/1.73 m². Mean increase in plasma creatinine was 16.6 µmol/l (SD=16.3). None of the clinical parameters were significant predictors for QoL. Female gender was significantly associated with general fatigue. There was a significant difference in perception of recognition from health personnel between donors with hypertension and donors without hypertension.
CONCLUSIONS: Our results show no associations between clinical and self-reported outcomes. However, we found a significant relationship between hypertension and donation-specific outcomes. Hypertension or reduced kidney function was identified in a minority of the donors. The increased risk for fatigue among female donors needs more investigation.

Keywords: Kidney Transplantation, Patient Outcome Assessment, Quality of Life, Time, Tissue and Organ Procurement

Related Articles (0)

Coming Soon...

Published: 2017-03-17

Conversion from Calcineurin Inhibitor-Based Immunosuppression to Mycophenolate Mofetil in Monotherapy Red...

Diego Aguiar, Diego Martínez-Urbistondo, Delia D'Avola, Mercedes Iñarrairaegui, Fernando Pardo, Fernando Rotellar, Bruno Sangro, Jorge Quiroga, Jose Ignacio Herrero

Ann Transplant 2017; 22:141-147

DOI: 10.12659/AOT.901556

Published: 2017-03-14

Ruptured Hemangioma of a Native Kidney: An Unusual Cause of Postoperative Hemorrhage in Kidney Transplant...

Grażyna Poznańska, Michał Wlazlak, Piotr Hogendorf, Dariusz Szymański, Janusz Strzelczyk, Adam Durczyński

Ann Transplant 2017; 22:138-140

DOI: 10.12659/AOT.901149