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Atherogenesis Markers in Patients with Chronic Rejection of Renal Allografts

Ondrej Viklicky, Stefan Vitko, Jan Kvasnicka, Vladimir Teplan

Ann Transplant 2001; 6(2): 16-18

ID: 498318

Published: 2001-06-08


Patients with renal insufficiency are thought to be at the higher risk of atherosclerosis complications. In the present study we evaluated some atherogenesis risk factors in patients with biopsy proven chronic vascular rejection of transplanted kidney and compared them with matched groups of transplant recipients. Patients with chronic rejection had higher plasma levels of alfa-I-acid glycoprotein and fibrinogen as well as soluble P-selectin level. Surprisingly we found no differences in other adhesion molecules. In conclusion, patients with chronic renal graft rejection are at the higher risk of atherosclerosis development.

Keywords: acute phase protein, renal transplantation, chronic rejection



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