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Similar Response of Dendritic Cells to Bacterial and Allogeneic Antigens

J Stanisławska, B Interewicz, M Maksymowicz, W L Olszewski

Ann Transplant 2003; 8(4): 27-30

ID: 7544

Published: 2002-12-15


The dendritic cells (DC) of an allograft recipients become engaged not only in an allogeneic but also antibacterial reaction. They react to the
alloantigens and microorganisms which colonize the rejecting grafts. This leads to overstimulation of DCs what may non-specifically intensify the rejection process. We investigated the effects of allogeneic and bacterial antigens on splenic DCs phenotypes. In vitro stimulation of spleen DCenriched population by E. coli, LPS and CpG DNA brought about an increase in expression of OX6 (MHC class II) from 47,4% in the control population to 65% in the E. coli stimulated group (p

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