Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Facial Transplantation

M Siemionow

Ann Transplant 2009; 14(1): 19-20 :: ID: 880269

Abstract

Twenty years of experience with composite tissue allograft models is presented. First, the experimental models of microcirculatory response to ischemia and reperfusion injury and surgical trauma are discussed, with presentation of the intravital microscopy system for direct in vivo observation of the microcirculation of the composite tissue allograft transplants. The intravital microscopy system presents responses to hemodynamic changes, leukocyte en-dothelial interactions, and permeability of the grafts under different ischemic conditions and under the trauma of transplantation surgery. These studies served as a baseline for establishment of treatment protocols for composite tissue allograft transplants. As a result, the meticulous surgical techniques and shortening of ischemia time and reperfusion injury, were considered in development of the experimental models for composite tissue transplantation. The model of rat hind limb transplantation, across major histocompatibility barrier, is presented as a standard model for evaluation of graft rejection, and for testing of tolerance induction, under different immunosuppression and immunomodulation protocols. The outcome of the treatment protocols for induction of tolerance and chimerism is discussed. The evolution of composite tissue allograft models from limb transplantation to groin transplantation and face transplantation, is discussed.
The models of full face transplantation, hemi-face transplantation, and composite facial- cranial, and facial-maxilla transplantation, are presented with different immunosuppression protocols. Finally, in preparation for face transplantation, cadaver studies evaluating the technical feasibility of a full face transplant and evaluation of the surface area for face and scalp transplantation, are discussed. These 20 years of research in the field of composite tissue allograft transplantation are presented as the basis for the first IRB approval for facial allograft transplantation in humans, leading to the first face transplantation surgery performed in the United States, in December 2008. Objectives:
1. At the end of the session, the participant will be able to understand background information regarding the need for facial transplantation.
2. At the end of the session, the participant will be able to understand experimental animal studies and cadaver studies performed in preparation for facial transplantation.
3. At the end of the session, the participant will be able to understand that
the first IRB approval for facial allograft transplantation in humans was based on over 20 years of extensive research in the field of composite tissue allograft transplantation.

Keywords: experimental models

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358