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ABCC2 SNP 4445 G>a in kidney allograft recipients

J Pazik, M Ołdak, M Puzon, E Sitarek, Z Lewandowski, R Maksym, R Płoski, J Malejczyk, M Durlik

Ann Transplant 2009; 14(1): 35-35

ID: 880326

Published: 2009-05-21


Chronic kidney disease (CKD) is associated with multiple hereditary predisposing factors. Multidrug resistance associated protein (MDR2) is an efflux pump engaged in terminal excretion of endogenous and xenobiotic anions, expressed on the apical surface of proximal tubular cells. To our knowledge MDR2 SNP polymorphisms have not been identified as CKD risk factor. In a case-control study 165 kidney allograft recipients and 180 blood donors were genotyped for ABCC2 4445 G>A. Distribution of ABCC2 4445 G>A results in control group were as follow: 84% GG homozygotes, 14% GA heter-ozygotes, 1.7% AA, as in general population. In kidney allograft recipients diminished frequency of allele A was found - 94.5% of individuals carried GG, 4.9% GA, 0.6% AA (P<0.005; Fisher's Exact Test). We can only speculate whether allele A's presence is associated with diminished risk of ESRD or, on the contrary, in dialysed individuals with a burden of morbid conditions precluding kidney transplantation and at last increased risk of early allograft loss. Further studies in chronic kidney disease patients are required to evaluate our finding.

Keywords: Kidney Transplantation



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