Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Correlation between selected prognostic factors and a postoperative course in liver transplant recipients

W Patkowski, K Zieniewicz, M Skalski, M Krawczyk

Ann Transplant 2009; 14(1): 40-40 :: ID: 880343

Abstract

The objective was to identify the major prognostic factors influencing the
liver function after the transplantation and predicting postoperative course and long-term survival in liver transplant recipients. We have analyzed results of biochemical, microbiological, serological, pathological studies of the donor and recipient, as well as intraoperative data (type of implantation, cold and warm ischemia time, total operation time, post-reperfusion syndrome, bile ducts drainage, degree of liver steatosis, anatomic variations). 215 of 542 liver transplant recipients (39.7%) were analyzed in the period 1989-2006. Patients were selected and divided according to the different mechanism leading to the liver disease. Group I - HCV infection, 80 patients (37.0%). Group II - HBV infection, 33 patients (15.0%). Group III - HBV and HCV infection, 13 patients (6.0%). Group IV - ALD, 66 patients (31.0%). Group V - AIH, 23 patients (11.0%). It was proved that patient survival prediction based on clinical parameters had a better prognostic value than prediction based only on the liver function tests. Transplant urgency scores: MELD, delta MELD and UNOS enables to predict early and long-term patient's survival after liver transplantation. Update of these scores, adequately to the patient's condition enables to evaluate effectively pre-transplantation life-threatening factors and urgency level. For organ donation predictive factors are: age, viral status and a degree of liver steatosis. Cold and warm ischemia time still has been a major prognostic factor. Routine biliary drainage resulted in worse long-term survival than in non-drained patients. Liver transplantation due to ALD was affected with the highest complications ratio. Chronic liver rejection occurred more frequently in AIH transplanted group. The most useful predictive factors of 1-year survival are liver function tests (AST, ALT, GGTP, INR, Quick) and urea/creatinine.

Keywords: Liver Transplantation

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358