21 May 2009
Prevalence and predictors of acute kidney injury in liver transplant recipients
A Rymarz, M Serwacki, M Rutkowski, K Pakosiński, M Grodzicki, W Patkowski, U Ołdakowska-Jedynak, A Kącka, M KrawczykAnn Transplant 2009; 14(1): 41-41 :: ID: 880348
Abstract
Background: Renal failure is a major impact factor of liver transplant outcome and renal function impairment predicts decreased survival, leading to increased morbidity and mortality. The aim of the study was to estimate the incidence, risk factors and resolution of acute kidney injury (AKI) in liver transplant recipients during post-operative hospital stay.
Material/Methods: We analyzed retrospectively data of 99 liver transplant recipients operated in 2008. Post-transplant occurrence of AKI was defined as an increase in serum creatinine concentration (SCr) of 0.3 mg/dl or more (1.5 - fold from baseline). Recipient's age, aetiology of underlying liver disease, pre-transplant arterial hypertension, pre-transplant diabetes mellitus, pre-transplant SCr level, MELD score, Child-Pugh score, hypotension during operation, utilization of exogenous vasoconstrictors, number of packed red blood cells infused during operation were collected for each patient.
Results: AKI was observed in 31.31% of liver transplant recipients (31 patients). In this group mean increase in SCr was 2.49 (±0.78) fold from the baseline. Mean post-transplant SCr level was 2.59 (±0.92) mg/d. Renal replacement therapy was introduced in 16.12% (5 pts) of liver recipients developing AKI. Among them 2 pts (6.45%) died. Mean SCr level at the time of discharge from hospital was 1.17 (±0.57) mg/dl in the group of AKI in comparison with 0.77 (±0.32) in the group without AKI. Mean MELD score in AKI group was 17.19 (±7.65), mean Child-Pugh score 8.48 (±2.05). Mean number of packed red blood cells infused during operation was 4.89 (±3.71). Pre-transplant diabetes mellitus, Child-Pugh score, treatment with exogenous vasoconstrictors, number of packed red blood cells infused during operation correlated with occurrence of AKI in liver transplant recipients.
Conclusions: Our study demonstrates that AKI after liver transplantation is a relatively common complication. The Child-Pugh score, pre-transplant diabetes, treatment with exogenous vasoconstrictors, number of packed red blood cells infused during operation were identified as pre-transplant variables related to occurrence of AKI.
Keywords: Liver Transplantation
In Press
08 Mar 2024 : Original article
Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...Ann Transplant In Press; DOI: 10.12659/AOT.943532
14 Mar 2024 : Original article
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort StudyAnn Transplant In Press; DOI: 10.12659/AOT.943652
14 Mar 2024 : Case report
Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...Ann Transplant In Press; DOI: 10.12659/AOT.942358
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860