J Pinocy-Mańdok, J Chudek, A Kolonko, A Wiecek
Ann Transplant 2009; 14(1): 51-51
Background: Both anaemia and erythrocytosis frequently occur after kidney
transplantation (KTx). However their inï¬‚ uence on cardiovascular complications and the risk of kidney graft loss is not well documented. The aim of this study was to analyze the inï¬‚uence of both anaemia and erythrocytosis on kidney graft function and patients outcome in a long-term follow-up after kidney transplantation.
Material/Methods: Two hundred ninety nine consecutive patients with at least 12-month post successful kidney transplantation were enrolled in this study. 90.1% of analysed patients had completed a 5-year follow-up period. Anaemia occurred in 29.5% of patients (in 16.1% Hb <11.0g/dl), while erythrocytosis in 19.1% of patients (including 9.0% with Ht >55%). We have analysed the graft function 12 months after KTx and the impact of anaemia or erythrocytosis on 5-year risk of death and graft loss.
Results: In 58% of anaemic patients low haemoglobin concentration did not
reach normal range in the whole observation time after KTx. The mean eGFR-
MDRD 12 months post KTx was significantly lower in patients with anaemia
(44.9±18.8 ml/min vs. 52.9±17.0 ml/min;p=0.01). Better 12-month graft function was observed in patients with erythrocytosis (59.0±18.4 ml/min). Anaemia but not erythrocytosis was associated with the increased risk of graft loss [RR=3.79 (1.97-7.29); p<0.001]. The risk of death was similar in all subgroups.
Conclusions: Anaemia after KTx is associated with a worse kidney graft function and is a strong predictor of graft loss. Erythrocytosis occurs in patients with excellent kidney graft function; nonetheless it did not increase the risk of graft loss or death when properly treated with phlebotomy.
Keywords: Kidney Transplantation