Improving the function of the kidney graft by verapamil– does it depend on metabolic or haemodynamic effect?
M Nowacki, M Droździk, K Ciechanowski, L Domański, K Safranof, Z Zietek, J Sienko, M Romanowski, T Sulikowski, M Kaminski, K Pabisiak, M Ostrowski
Ann Transplant 2009; 14(1): 58-58
The aim of this study was to evaluate inï¬‚uence of Verapamil on the function of the transplanted kidney three months after transplantation and inï¬‚uence of changing vessel resistance by Verapamil on the functioning transplanted kidney.
Material/Methods: 48 cadaver kidney donors and 96 transplanted patients. The analysed group was 48 kidneys that received injection of 100 μg of Verapamil directly into renal artery 2 minutes before beginning perfusion. The control group was 48 kidneys from the same pair without pre-conditioning with Verapamil.
Results: The level of kidneys' perfusion after adding Verapamil was significantly higher comparing to perfusion of kidneys without adding Verapamil (SD 161 ml/min vs. 111 ml/min). Recipients from the group, that received kidneys after adding Verapamil reached faster the level of 2.0 mg/dL of serum creatinine than recipients from the control group (p<0.005). Level of perfusion did not inï¬‚uence reaching 2.0 mg/dL serum creatinine level in both groups of recipients (p<0.05)
Conclusions: We noticed that Verapamil improves the kidney graft function in the first three months after transplantation. Verapamil reduces kidney's vessel resistance but it does not correlate with improving the function of the kidney after transplantation, however this effect could depend on metabolic effect [blocking calcium channels].
Keywords: Ischemia reperfusion injury, Kidney Transplantation, Organ Perfusion