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Increased Plasma TGF-beta 1 Level in Patient with Salivary Gland Carcinoma After Renal Transplantation

M Boratynska, E Watorek, K Falkiewicz, M Banasik

Ann Transplant 2005; 10(2): 16-19

ID: 16808


TGF-beta1 maintains homeostasis of rapidly proliferating cells, therefore is a potential tumor suppressor of non-malignant cells. Malignant transformation alters TGF-beta1 signalling pathway, turning it into a stimulator of tumor progression. We describe the case of 54 year old renal transplant patient with highly increased plasma TGF-beta1 level and planoepithelial carcinoma originating from parotid salivary gland. We discuss the role of TGF-beta1 in promotion of carcinogenesis and probable utility in prognosis of malignancy.

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