28 March 1996
Graft rejection in sensitized recipients
J W Kupiec-WegliitskiAnn Transplant 1996; 1(1): 34-40 :: ID: 496608
Abstract
Recipient sensitization to MHC antigens is among the most critical of problems currently facing clinical transplantation in terms of magnitude and impact. Approximately 20% of all patients awaiting kidney transplantation have elevated levels of broadly reactive alloantibodies, resulting from multiple transfusions. prior failed allografts.or pregnancy. These highlysensitized patients experience an increased rate of graft rejection, compared to unsensitized individuals. which is often irreversible and difficult to control by currently used immunosuppressive agents. The evidence suggests that the common denominator in the pathogenesis of allograft rejection in presensitized recipients is the combined cellular and humoral immune alloreactivity. Although the relative significance of these responses varies. all successful immunosuppressive therapies have common three elements of diminished or abrogated mononuclear cell activation, cytokine expression. and endothelial cell activation. The main target for the antibody-mediated damage, the vascular endothelium, may also be affected by nonspecific effector mechanisms, complement, coagulation. phagocytic cells. and their products. The dissection and better apprteciation of the complexity of the rejection cascade may be important for the much needed progress in the management of allograft rejection in sensitized hosts. and may provide insights relevant to the development of xenotransplantation.
Keywords: allograftrejection, sensitized recipients, Cytokines, Immunomodulation
In Press
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
18 Mar 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of R...Ann Transplant In Press; DOI: 10.12659/AOT.943282
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860