eISSN 2329-0358


Get your full text copy in PDF

Antibodies and chronic organ graft rejection

L C Paul

Ann Transplant 1997; 2(2): 46-52

ID: 497155

The development of chronic rejection within weeks or months after transplantation in allogeneic organ transplan ts provides a compelling case in favour of the hypothesis that alloimmune reactions playa major pathogenetic role in this syndrome. Although most if not all of the lesions of chronic rejection can also emerge in syngeneic transplants [1,2], it usually takes a much longer time interval to develop in such grafts. In experimental animals, retransplantation of allogeneic kidney or heart transplants back into the original donor strain often prevents the development of chronic rejection if done within a certain time frame [3,4], suggesting that persistent alloimmune reactivity is required for the induction chronic rejection.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree