eISSN 2329-0358

Logo



Get your full text copy in PDF

NRP 8/14 and Procalcitonin Serum Levels in Organ Transplantations

I Striz, M Jaresova, J Lacha, J Sedlacek, S Vitko

Ann Transplant 2001; 6(2): 6-9

ID: 497582


Objectives: MRP8/ 14is a heterodimer of two myeloid calcium-binding proteins associated with different types of acute inflammatory processes. We studied MRP8/14 together with procaJcitonin (PeT) serum levels in order to diagnose infectious complications or the rejection process affecting kidney or heart allograft. Methods: A total of 419 serum samples was evaluated. MRP8/ 14 levels were measured by ELISA (BMA Biomed), PCT by a sensitive immunoluminiscent assay ILMA (Brahms Diagn.) Results: Both parameters showed very low basal levels in healthy subjects (range 303-1,660 ng/ml of MRP8/ 14; less than 0.08 ng/ml of PeT). A rapid increase in serum levels occurred in response to bacterial infections (MRP8/14 up to 6,230 ng/ml; PCT up to 297 ng/ml). Serum PCT concentration remained low in the presence of kidney allograft rejection, where MRP8/ 14 levels were increased. An uncomplicated outcome of kidney or heart transplantation did not change basal serum MRP8/ 14 and PCT levels. Conclusions: We condude that I) both MRP8/ 14 and PCT are very sensitive markers of complications in organ transplant recipients (normal values in uncomplicated outcome) 2) combination of both parameters is useful to discriminate between rejection (increased MRP8/ 14 with normal PeT) and systemic bacterial infection (both parameters increased).

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree