eISSN 2329-0358

Logo



Get your full text copy in PDF

Progressive arterial stiffening in kidney transplant recipients

Paweł Strozecki, Andrzej Adamowicz, Michal Kozlowski, Zbigniew Wlodarczyk, Jacek Manitius

Ann Transplant 2011; 16(3): 30-35

ID: 881992


Background:    Pulse wave velocity (PWV) is a marker of arterial stiffness. Data from general population and end-stage renal disease patients suggest that PWV increases with age by about 0.1 m/s for each year of life and that PWV increase is steeper after the fifth decade. Recent follow-up studies showed decrease of arterial stiffness during the first year after kidney transplantation (KTx). This study aimed to investigate PWV change in kidney transplant recipients (KTR) during long-term follow-up.
    Material/Methods:    Carotid-femoral PWV was measured at baseline (PWV1) and then after at least 24 months (range 24–34, mean ±SD 28±3) of follow-up (PWV2) in 61 KTR aged 46±12 years. Baseline PWV measurements were performed at 36±27 months (range 4–121) after KTx. Clinical and laboratory data were also analyzed. GFR was calculated with MDRD formula (eGFR). ∆PWV was calculated as (PWV2-PWV1)/PWV1.
    Results:    Significant increase in PWV (9.1±1.7 vs. 9.8±2.0; p<0.002) and pulse pressure (PP) (50±11 vs. 53±14; p<0.05) was found during follow-up, but systolic, diastolic and mean arterial pressure did not change. eGFR did not change during follow-up (55±16 vs. 56±16 ml/min/1.73 m2). PWV increase was observed in patients aged ≥50 years (9.8±1.8 vs. 10.8±1.9; p<0.01), while not in younger patients (8.5±1.5 vs. 8.9±1.5; p=0.14). Significant positive correlation was found between ∆PWV and duration of the follow-up period.
    Conclusions:    The study revealed progressive arterial stiffening in kidney transplant recipients during long-term follow-up. Further studies are necessary to explain the pathophysiology of this phenomenon.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree