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Recent Developments in Transplantation and Transfusion Medicine

Hisham A. Edinur, Geoffrey K. Chambers, Paul P.J. Dunn

(Human Identification Unit, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia)

Ann Transplant 2015; 20:424-429

DOI: 10.12659/AOT.894003


ABSTRACT: Transplantation and transfusion are related and clinically important areas of multidisciplinary expertise, including pre-operative treatment, donor recruitment, tissue matching, and post-operative care. We have seen significant developments in these areas, especially in the late 20th and early 21st century. This paper reviews the latest advances in modern transplantation and transfusion medicine, including several new genetic markers (e.g., major histocompatibility complex class I chain-related gene A, killer cell immunoglobulin-like receptor, and human platelet antigens) for donor and recipient matching, genotyping platforms (e.g., next-generation sequencer and Luminex technology), donor recruitment strategies, and several clinical applications in which genotyping has advantages over agglutination tests (e.g., genotyping of weakly expressed antigens and determination of blood groups and human leukocyte antigen types in multi-transfused patients). We also highlight the roles of population studies and international collaborations in moving towards more efficient donor recruitment strategies.

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