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14 July 2020 : Original article  

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma1ABCDEFG*, Hidehiro Tajima1AC, Hiroyuki Takamura1ACG, Seisho Sakai1A, Ryosuke Gabata1B, Mitsuyoshi Okazaki1B, Hiroyuki Shinbashi1B, Yoshinao Ohbatake1B, Isamu Makino1B, Hironori Hayashi2A, Tomoharu Miyashita1AC, Sachio Fushida1A, Tetsuo Ohta1ACE

DOI: 10.12659/AOT.922306

Ann Transplant 2020; 25:e922306

Figure 2 Macroscopic findings: Before ischemia of the liver, both the liver and small intestine showed no abnormalities. After 30 min of ischemia of the liver, the liver surfaces appeared ischemic and the small intestines became distended, congested, and dark red (A). Five hours after reperfusion, the liver surfaces of the ischemia–reperfusion (IR) and IR+milrinone groups appeared brown and slightly congested. The small intestines of the IR group remained congested and slightly distended. These findings in the small intestines were attenuated in the IR+milrinone group (B). White arrows, small intestine.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358