14 July 2020: Original Paper
Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats
Shinichi Nakanuma 1ABCDEFG* , Hidehiro Tajima 1AC , Hiroyuki Takamura 1ACG , Seisho Sakai 1A , Ryosuke Gabata 1B , Mitsuyoshi Okazaki 1B , Hiroyuki Shinbashi 1B , Yoshinao Ohbatake 1B , Isamu Makino 1B , Hironori Hayashi 2A , Tomoharu Miyashita 1AC , Sachio Fushida 1A , Tetsuo Ohta 1ACEDOI: 10.12659/AOT.922306
Ann Transplant 2020; 25:e922306
Figure 2 Macroscopic findings: Before ischemia of the liver, both the liver and small intestine showed no abnormalities. After 30 min of ischemia of the liver, the liver surfaces appeared ischemic and the small intestines became distended, congested, and dark red (A). Five hours after reperfusion, the liver surfaces of the ischemia–reperfusion (IR) and IR+milrinone groups appeared brown and slightly congested. The small intestines of the IR group remained congested and slightly distended. These findings in the small intestines were attenuated in the IR+milrinone group (B). White arrows, small intestine.