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14 July 2020 : Original article  

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma1ABCDEFG*, Hidehiro Tajima1AC, Hiroyuki Takamura1ACG, Seisho Sakai1A, Ryosuke Gabata1B, Mitsuyoshi Okazaki1B, Hiroyuki Shinbashi1B, Yoshinao Ohbatake1B, Isamu Makino1B, Hironori Hayashi2A, Tomoharu Miyashita1AC, Sachio Fushida1A, Tetsuo Ohta1ACE

DOI: 10.12659/AOT.922306

Ann Transplant 2020; 25:e922306

Figure 5 Assessment of cleaved caspase-3 expression in the liver parenchyma: The sham group had no cleaved caspase-3-positive cells in the hepatic parenchyma. In the ischemia-reperfusion (IR) group, cleaved caspase-3 was expressed in the cytoplasm of the hepatocytes (black arrows) around the necrotic area (*) in the pericentral zone (zone 3). The IR+milrinone group had fewer cleaved caspase 3-positive hepatocytes (A). The IR group had significantly more cleaved caspase-3-positive hepatocytes in zone 3 than in the periportal zone (zone 1). The IR+milrinone group had significantly fewer cleaved caspase-3-positive hepatocytes in zone 3 than did the IR group (B). * Significantly different (P<0.05) from zone 1 of the IR group. # Significantly different (P<0.05) from the IR group of the same zone. CV – central vein.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358