14 July 2020 : Original article
Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats
Shinichi Nakanuma1ABCDEFG*, Hidehiro Tajima1AC, Hiroyuki Takamura1ACG, Seisho Sakai1A, Ryosuke Gabata1B, Mitsuyoshi Okazaki1B, Hiroyuki Shinbashi1B, Yoshinao Ohbatake1B, Isamu Makino1B, Hironori Hayashi2A, Tomoharu Miyashita1AC, Sachio Fushida1A, Tetsuo Ohta1ACEDOI: 10.12659/AOT.922306
Ann Transplant 2020; 25:e922306
Figure 6 Histological changes of small intestine related to hepatic ischemia-reperfusion (IR) injury: In the IR group, the ilea showed severe congestion in the lamina propria with shortened villi. In the IR+milrinone group ilea, the villus architecture was preserved, and the congestion was decreased (A). The Park and congestion scores in the villi of the IR group were significantly higher than those of the sham group. These villus scores of the IR+milrinone group were significantly decreased as compared with those of the IR group. The IR group villi were lower than those of the sham group (B–D). * Significantly (P<0.001) different from the sham group. # Significantly (P<0.05) different from the IR group.