14 July 2020 : Original article
Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats
Shinichi Nakanuma1ABCDEFG*, Hidehiro Tajima1AC, Hiroyuki Takamura1ACG, Seisho Sakai1A, Ryosuke Gabata1B, Mitsuyoshi Okazaki1B, Hiroyuki Shinbashi1B, Yoshinao Ohbatake1B, Isamu Makino1B, Hironori Hayashi2A, Tomoharu Miyashita1AC, Sachio Fushida1A, Tetsuo Ohta1ACEDOI: 10.12659/AOT.922306
Ann Transplant 2020; 25:e922306
Figure 7 Assessment of cleaved caspase-3 expression in the small intestine: The sham group ilea contained no cleaved caspase-3-positive cells. In the ischemia–reperfusion (IR) group, some cells were strongly positive for cleaved caspase-3 expression (black arrows), mainly at the lamina propria, with congestion. The IR+milrinone group ilea had fewer of these cells (A). The small intestines of the IR+milrinone group had significantly fewer of these cells than did the IR group (B). # Significantly different (P<0.01) from the IR group.