Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma; Hidehiro Tajima; Hiroyuki Takamura; Seisho Sakai; Ryosuke Gabata; Mitsuyoshi Okazaki; Hiroyuki Shinbashi; Yoshinao Ohbatake; Isamu Makino; Hironori Hayashi; Tomoharu Miyashita; Sachio Fushida; Tetsuo Ohta

doi:10.12659/AOT.922306

14 July 2020: Original Paper

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma ^1ABCDEFG* , Hidehiro Tajima ^1AC , Hiroyuki Takamura ^1ACG , Seisho Sakai ^1A , Ryosuke Gabata ^1B , Mitsuyoshi Okazaki ^1B , Hiroyuki Shinbashi ^1B , Yoshinao Ohbatake ^1B , Isamu Makino ^1B , Hironori Hayashi ^2A , Tomoharu Miyashita ^1AC , Sachio Fushida ^1A , Tetsuo Ohta ^1ACE

DOI: 10.12659/AOT.922306

Ann Transplant 2020; 25:e922306

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Figure 9 Survival analysis (hepatic ischemia-reperfusion [IR] injury model with 45-min whole hepatic ischemia): Six of the 13 rats in the IR group died within 24 h after surgery. The 7-day survival rate of the IR group was 53.8%. Twelve of the 13 rats in the IR+milrinone group survived, and the 7-day survival rate was increased significantly to 92.3% (P=0.03).

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Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

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