Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma; Hidehiro Tajima; Hiroyuki Takamura; Seisho Sakai; Ryosuke Gabata; Mitsuyoshi Okazaki; Hiroyuki Shinbashi; Yoshinao Ohbatake; Isamu Makino; Hironori Hayashi; Tomoharu Miyashita; Sachio Fushida; Tetsuo Ohta

doi:10.12659/AOT.922306

14 July 2020 : Original article

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma^1ABCDEFG*, Hidehiro Tajima^1AC, Hiroyuki Takamura^1ACG, Seisho Sakai^1A, Ryosuke Gabata^1B, Mitsuyoshi Okazaki^1B, Hiroyuki Shinbashi^1B, Yoshinao Ohbatake^1B, Isamu Makino^1B, Hironori Hayashi^2A, Tomoharu Miyashita^1AC, Sachio Fushida^1A, Tetsuo Ohta^1ACE

DOI: 10.12659/AOT.922306

Ann Transplant 2020; 25:e922306

Authors information Article notes Copyright and License information

Related articles Order reprints Share article Share by email

View HTML version

Figure 9 Survival analysis (hepatic ischemia-reperfusion [IR] injury model with 45-min whole hepatic ischemia): Six of the 13 rats in the IR group died within 24 h after surgery. The 7-day survival rate of the IR group was 53.8%. Twelve of the 13 rats in the IR+milrinone group survived, and the 7-day survival rate was increased significantly to 92.3% (P=0.03).

Back to the Article

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Your Privacy