Self-Assembling Peptide Scaffold Carrying Neural-Cell Adhesion Molecule-Derived Mimetic-Peptide Transplantation Promotes Proliferation and Stimulates Neurite Extension by Modulating Tau Phosphorylation and Calpain/Glycogen Synthase Kinase 3 beta (GSK-3β) in Neurons

Jian Xu; Jing Feng; Yu-dong Liu; Tao Hu; Ming-jing Li; Fan Li

doi:10.12659/AOT.924093

07 July 2020 : Original article

Self-Assembling Peptide Scaffold Carrying Neural-Cell Adhesion Molecule-Derived Mimetic-Peptide Transplantation Promotes Proliferation and Stimulates Neurite Extension by Modulating Tau Phosphorylation and Calpain/Glycogen Synthase Kinase 3 beta (GSK-3β) in Neurons

Jian Xu^1BCDEF, Jing Feng^2BCDF, Yu-dong Liu^1BCD, Tao Hu^1BCF, Ming-jing Li^1BF, Fan Li^1ACDEG*

DOI: 10.12659/AOT.924093

Ann Transplant 2020; 25:e924093

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Figure 3 Evaluation of proliferation and apoptosis of neurons in different groups. (A) Determination for the survival rates of DRG and SCMN neurons using MTT assay in FRM, FRM-MP, FRM-LiCl, and FRM-MP-LiCl groups. (B) Determination of apoptosis of DRG and SCMN neurons using flow cytometry assay in FRM, FRM-MP, FRM-LiCl, and FRM-MP-LiCl groups. Apoptosis rate, calculated as early apoptosis rate plus late apoptosis. * p<0.05 vs. FRM group. # p<0.05 vs. FRM-MP group.

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Self-Assembling Peptide Scaffold Carrying Neural-Cell Adhesion Molecule-Derived Mimetic-Peptide Transplantation Promotes Proliferation and Stimulates Neurite Extension by Modulating Tau Phosphorylation and Calpain/Glycogen Synthase Kinase 3 beta (GSK-3β) in Neurons

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