Pharmacodynamic Drug–Drug Interaction on Human Peripheral Blood Mononuclear Cells Between Everolimus and Tacrolimus at the Therapeutic Concentration Range in Renal Transplantation

Masaaki Okihara; Hironori Takeuchi; Shinichi Akiyama; Reichi Yoshinaga; Sayuri Osato; Isao Akashi; Yu Kihara; Osamu Konno; Hitoshi Iwamoto; Takashi Oda; Sachiko Tanaka; Sakae Unezaki; Toshihiko Hirano

doi:10.12659/AOT.928817

26 February 2021: Original Paper

Pharmacodynamic Drug–Drug Interaction on Human Peripheral Blood Mononuclear Cells Between Everolimus and Tacrolimus at the Therapeutic Concentration Range in Renal Transplantation

Masaaki Okihara ^1BDEF , Hironori Takeuchi ^2ABCD , Shinichi Akiyama ^3BCD , Reichi Yoshinaga ^3BCD , Sayuri Osato ^3BCD , Isao Akashi ^1B , Yu Kihara ^1B , Osamu Konno ^1B , Hitoshi Iwamoto ^4EF , Takashi Oda ^4EF , Sachiko Tanaka ^5AE , Sakae Unezaki ^3AE , Toshihiko Hirano ^5ADEF*

DOI: 10.12659/AOT.928817

Ann Transplant 2021; 26:e928817

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Figure 4 The interaction indices of TAC and EVL against Con A-activated proliferation of PBMCs.

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Pharmacodynamic Drug–Drug Interaction on Human Peripheral Blood Mononuclear Cells Between Everolimus and Tacrolimus at the Therapeutic Concentration Range in Renal Transplantation

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