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18 November 2022: Original Paper

Altered Serum Bile Acid Profile Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients

Yamei Li 1ACDE , Hua Zhang 23CFG , Xinhua Dai 1BC , Yunfei An 1BD , Yi Li 1AD , Lin Yan 1EF , Yunying Shi 4EF , Jiwen Fan 1BC , Xingxin Gong 1BDF , Lei Zhang 1D , Yuangao Zou 1F , Lanlan Wang 1AG , Yangjuan Bai 1ADE*

DOI: 10.12659/AOT.937974

Ann Transplant 2022; 27:e937974

Figure 3 Differential correlation analyses of various BAs between HC and KTR groups. Network analysis illustrates the differential correlation of BAs between study groups (A–C). Only BA pairs with significant differential correlations (P<0.05) were included. The colored lines connecting BAs indicates the direction and strength of the correlation groups, and the number of lines that follows indicates the number of BA pairs in the global networks exhibiting this pattern of change. For instance, the red line +/0 1 in Figure 3A indicates that the correlation between GCA and GDCA was positive (+) in the HC group, but the correlation disappeared (0) in the STA group. Only 1 BA pair connected by red line in the network displayed this pattern of change (+/0). +P<0.05, ++P<0.01, are positively correlated; −P<0.05, is negatively correlated; 0, represents unrelated. Differential correlation coefficients between BA pairs were calculated with the “DGCA” package and the visualization of correlation networks were achieved using Cytoscape software (Version 3.7.2).

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358