Figure 3 Differential correlation analyses of various BAs between HC and KTR groups. Network analysis illustrates the differential correlation of BAs between study groups (A–C). Only BA pairs with significant differential correlations (P<0.05) were included. The colored lines connecting BAs indicates the direction and strength of the correlation groups, and the number of lines that follows indicates the number of BA pairs in the global networks exhibiting this pattern of change. For instance, the red line +/0 1 in Figure 3A indicates that the correlation between GCA and GDCA was positive (+) in the HC group, but the correlation disappeared (0) in the STA group. Only 1 BA pair connected by red line in the network displayed this pattern of change (+/0). +P<0.05, ++P<0.01, are positively correlated; −P<0.05, is negatively correlated; 0, represents unrelated. Differential correlation coefficients between BA pairs were calculated with the “DGCA” package and the visualization of correlation networks were achieved using Cytoscape software (Version 3.7.2).