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25 February 2023: Original Paper

Detecting Donor-Derived DNA by Real-Time PCR in Recipients Suspected of Graft-Versus-Host-Diseases After Liver Transplantation: A Case Series and Literature Review

Changhee Ha 1ABCDEF* , Sang Jin Kim 234ABCDEF* , Jong Man Kim 2BE , Jae-Won Joh 2BE , Kee-Taek Jang 5BE , Gyu-Seong Choi 2ABCDE* , Eun-Suk Kang 1ABCDE*

DOI: 10.12659/AOT.938287

Ann Transplant 2023; 28:e938287

Figure 2 Timeline of recipients’ medical history and clinical courses (post-operative date unscaled); (A) Case 1, (B) Case 2, and (C) Case 3. Green arrow – skin or sigmoidoscopic biopsy; Red arrow – initiation of graft-versus-host disease treatment; Blue arrow – chimerism assay. Cytopenia and CMV related events are in red font. Figure created using PowerPoint 2016 (Microsoft Inc., Redmond, WA, USA). CMV – cytomegalovirus; POD – post-operative date; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; C – CMV antigenemia or qPCR (+); D – diarrhea; R – rash; F – fever; N – neutropenia; E – died; P – pancytopenia; I – Influenza positivity; IHC – immunohistochemistry; CH – CMV IHC (+); EGD – esophagogastroduodenoscopy; qPCR – real-time quantitative polymerase chain reaction.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358