Figure 1 Case 1: Tongue squamous cell carcinoma after liver transplantation. (A) Non-homogeneous lesion with underlying invasive SCC on the left lateral border and ventral surface of the tongue. (B) Surgical defect after partial glossectomy. (C) Primary closure of the tongue defect. (D) Left selective neck dissection (levels IA-III). (E) Low-power hematoxylin-and-eosin-stained section showing dysplastic squamous epithelium with irregular proliferation and invasion of tumor nests into the lamina propria and underlying stroma, accompanied by a dense chronic inflammatory infiltrate (original magnification ×100). (F) Medium-power view demonstrating infiltrating nests of atypical squamous cells with abundant eosinophilic cytoplasm and keratin pearl formation in a desmoplastic stroma, consistent with well- to moderately differentiated SCC (original magnification ×200). (G) Medium-power view highlighting pronounced nuclear pleomorphism, prominent nucleoli, frequent mitotic figures, and keratinized tumor nests (original magnification ×200). SCC – squamous cell carcinoma.