Figure 2 Case 2: Surgical reconstruction after extended hemiglossectomy. (A) Low-power hematoxylin-and-eosin-stained section demonstrating irregular nests of moderately differentiated SCC infiltrating the fibrous stroma, with multiple keratin pearls and a peritumoral lymphocytic infiltrate (original magnification ×100). (B) Medium-power view showing islands of atypical squamous cells with eosinophilic cytoplasm and keratinization within a desmoplastic stroma (original magnification ×200). (C) High-power view of the invasive front demonstrating pronounced nuclear atypia, an increased nuclear-to-cytoplasmic ratio, atypical mitotic figures, and focal keratin pearl formation (original magnification ×400). (D) Intraoral view showing an anterolateral thigh free flap reconstruction of the left lateral tongue and floor of the mouth after extended hemiglossectomy and neck dissection. SCC – squamous cell carcinoma.