Brain Death–Induced Systolic Ventricular Dysfunction and Its Association With NLRP3-Related Inflammatory Signaling in a Murine Model

Lei Huang; Kevin P. Zbierski; Ye Yuan; Siyuan Dong; Jacob Razzouk; David G. Rabkin

doi:10.12659/AOT.951930

09 June 2026 : Original article

Brain Death–Induced Systolic Ventricular Dysfunction and Its Association With NLRP3-Related Inflammatory Signaling in a Murine Model

Lei Huang^{ABCDEFG 1,2}, Kevin P. Zbierski^{B 3}, Ye Yuan^{CD 2}, Siyuan Dong^{CD 2}, Jacob Razzouk^{C 3}, David G. Rabkin

^{ABCDEFG 3*}

DOI: 10.12659/AOT.951930

Ann Transplant 2026; 31:e951930

Authors information Article notes Copyright and License information

Introduction Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Figure 4 Phase II levels of NLRP3 and pro-inflammatory cytokines in left ventricle at 60 minutes after brain death (BD). (A) Representative western blot bands from 2 independent animal sets; (B–E) Quantitative analysis of NLRP3, IL-1β, TNF-α, and IL-6 expressions. n=6/group. ** P<0.01, * P<0.05 vs control.

Back to the Article

Brain Death–Induced Systolic Ventricular Dysfunction and Its Association With NLRP3-Related Inflammatory Signaling in a Murine Model

Your Privacy