Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

20 April 2018 : Original article  

Does Ischemia Free Liver Procurement Under Normothermic Perfusion Benefit the Outcome of Liver Transplantation?

Qiang Zhao123E, Shanzhou Huang123BE*, Dongping Wang123A, Zhiheng Zhang123B, Linwei Wu123A, Lu Yang4B, Yi Ma123C, Fei Ji123C, Yunhua Tang123D, Linhe Wang123D, Zebin Zhu123D, Yanling Zhu5A, Wei Xiong4D, Maogen Chen123B, Ming Han623C, Jian Zhou123C, Anbin Hu123D, Guodong Wang123D, Xingyuan Jiao123E, Xiaofeng Zhu123A, Weiqiang Ju123E, Zhiyong Guo123E, Xiaoshun He123AE

DOI: 10.12659/AOT.909645

Ann Transplant 2018; 23:258-267

Abstract

BACKGROUND: In contrast to conventional static cold preservation, normothermic machine perfusion (NMP) provides a beneficial alternative preservation of donor livers. However, the liver still suffered cold ischemic injury before attaching to the perfusion device.

MATERIAL AND METHODS: To prevent cold ischemic injury during procurement, we describe a novel procedure called ischemia-free liver procurement (IFLP) under NMP. Two liver grafts were procured from brain death donor under NMP and underwent 2-hour ex vivo NMP followed by 3 and 6 hours of static cold preservation. From procurement to post-transplantation course, evidence was collected to prove that IFLP is safe and benefits recipients.

RESULTS: The post-transplantation course was uneventful, and the liver function tests and histological study revealed minimal hepatocyte and biliary epithelium injury during the preservation.

CONCLUSIONS: This preliminary experience demonstrates the clinical feasibility and safety of IFLP under NMP which offering opportunities to increase the number of donor livers and to improve the organ function.

Keywords: Liver Transplantation, Organ Preservation, Tissue and Organ Procurement

Add Comment 0 Comments

764 9

In Press

06 Jun 2023 : Original article  

A 15-Year Retrospective Study of Supportive Extracorporeal Therapies Including Plasma Exchange and Continuo...

Ann Transplant In Press; DOI: 10.12659/AOT.939745  

02 Jun 2023 : Original article  

Survival analysis of transplant-associated thrombotic microangiopathy under different diagnostic criteria a...

Ann Transplant In Press; DOI: 10.12659/AOT.939890  

10 May 2023 : Original article  

Incidence of Thromboembolic Complications Following Kidney Transplantation with Short and Extended Aspirin ...

Ann Transplant In Press; DOI: 10.12659/AOT.939143  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358