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21 June 2019 : Original article  

Haploidentical, Unmanipulated Granulocyte Colony-Stimulating Factor (G-CSF)-Primed Peripheral Blood Stem Cell Transplants for Acute Myeloid Leukemia (AML) in Remission: A Single Center Experience

Lan Luo1ABCDEF, Shu Fang1B, Shasha Zhao1B, Fei Li1B, Yu Zhou2C, Lixun Guan3B, Nan Yang1B, Zhenyang Gu1B, Tao Lin1B, Feiyan Wang1B, Chengying Zhu1B, Wenrong Huang1D, Daihong Liu1D, Chunji Gao1ACDFG*

DOI: 10.12659/AOT.915182

Ann Transplant 2019; 24:367-373

Abstract

BACKGROUND: Data about application of related haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) on patients with high-risk or intermediate-risk acute myeloid leukemia (AML) in the first complete remission (CR1) are lacking. In this study, we report the outcomes of using unmanipulated haploidentical allogeneic peripheral blood stem cell transplantation (haplo-PBSCT) as post-remission therapy for patients with high-risk or intermediate-risk AML in CR1.

MATERIAL AND METHODS: From January 2008 to July 2016, 33 patients diagnosed as high-risk or intermediate-risk AML in CR1 undergoing haplo-PBSCT in our institution were enrolled for analysis. The cumulative incidence of platelet and neutrophil recovery, the occurrence of acute graft-versus-host-disease (GVHD) and chronic GVHD, relapse and non-relapse mortality were assessed. Patients’ survival rates were estimated using the Kaplan-Meier method.

RESULTS: The cumulative incidence of grade 2-4 acute GVHD, overall and extensive chronic GVHD was 18.2%, 9.1%, and 6.1%, respectively. 2-year probability of relapse was 9.1%. Disease-free survival and overall survival at 2 years were 72.7% and 75.8%, respectively.

CONCLUSIONS: Our results showed that unmanipulated haploidentical transplantation with G-CSF primed PBSC alone as a graft source could be an acceptable alternative post-remission treatment for high-risk or intermediate-risk AML patients in CR1 lacking a matched donor.

Keywords: Bone Marrow Transplantation, Haploidy, Leukemia, Myeloid, Acute, Adolescent, Graft vs Host Disease, Granulocyte Colony-Stimulating Factor, Incidence, Peripheral Blood Stem Cell Transplantation, Survival Rate, Transplantation Conditioning, young adult

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358