12 November 2019 : Original article
Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients
Lin Yan1ADEF, Zhi-Qiang Yang1EF, Yun-Ying Shi2EG, Jing Ren1C, Cui-Li Yang1B, Zheng-Li Wan1B, Yang-Juan Bai1D, Li-Mei Luo1G, Lan-Lan Wang1DG, Yi Li1ADG*DOI: 10.12659/AOT.918980
Ann Transplant 2019; 24:594-604
Abstract
BACKGROUND: Tacrolimus is a widely used immunosuppressant in renal transplant recipients. It was demonstrated in rats and healthy volunteers that Wuzhi capsules could inhibit metabolism and maintain blood concentration of tacrolimus. However, there are no clinical studies of Wuzhi capsules in renal transplant recipients. This research aimed to assess the effect of Wuzhi capsules on the blood concentration of tacrolimus in renal transplant recipients.
MATERIAL AND METHODS: A total of 158 Chinese renal transplant recipients receiving tacrolimus with or without Wuzhi capsules were included in this retrospective study. The cohort study included 126 recipients, with 86 recipients receiving Wuzhi capsules (WZCs) and the other 40 recipients not receiving WZCs. Another 32 recipients were involved in a self-control study.
RESULTS: Dose- and body weight-adjusted trough concentrations (C0/D/W) of tacrolimus in the WZC group were found to be significantly higher than that in the non-WZC group (P<0.05). The improvement of C0/D/W by administration of Wuzhi capsules was more significant in CYP3A5 expressers than in non-expressers following subgroup analysis. Furthermore, the WZC group had a remarkably higher proportion of subjects who reached target tacrolimus concentration than in the non-WZC group, both in CYP3A5 expressers (P=0.01) and non-expressers (P<0.001). Multiple linear regression analysis and self-control analysis confirmed the positive impact of Wuzhi capsules on tacrolimus concentration (P<0.001).
CONCLUSIONS: Wuzhi capsules can increase tacrolimus trough concentration without adverse effects on allograft function, especially in CYP3A5 expressers. Efficient and convenient immunosuppressive effects on renal transplant recipients can be achieved by treatment including administration of Wuzhi capsules.
Keywords: Cytochrome P-450 CYP3A, Drugs, Chinese Herbal, Kidney Transplantation, Tacrolimus, Capsules, Cohort Studies, Immunosuppressive Agents, Living Donors, Polymorphism, Single Nucleotide, Retrospective Studies, young adult
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