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08 July 2022 : Original article  

[In Press] Management of Spontaneous Portosystemic Shunts in 231 Patients Who Underwent Living Donor Liver Transplantation: A Retrospective Study from a Single Center in Nagasaki, Japan

Takashi Hamada1ABCDEF, Masaaki Hidaka1ACDEF, Akihiko Soyama ORCID logo1ACDF, Takanobu Hara ORCID logo1ADF, Hajime Imamura ORCID logo1ADF, Hajime Matsushima ORCID logo1ADF, Takayuki Tanaka1ADF, Tomohiko Adachi1ADF, Kengo Kanetaka ORCID logo1DF, Susumu Eguchi1ADF

DOI: 10.12659/AOT.936371

Ann Transplant In Press; DOI: 10.12659/AOT.936371  

Available online: 2022-07-08, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule


We have ligated spontaneous portosystemic shunts (SPSS) in living donor liver transplantation (LDLT) when a postoperative interventional radiology (IVR) approach was impossible or the intraoperative hepatopetal flow was insufficient. This retrospective study from a single center in Nagasaki, Japan aimed to investigate the management of SPSS in 231 patients who underwent LDLT between January 2006 and December 2019.
SPSS were identified in 63 patients (27.3%). Perioperative factors and survival rates were compared in the study population with SPSS divided into 2 groups: the ligation group and the non-ligation group. The post-transplant course was examined in greater detail in the non-ligation group.
SPSS were ligated in 20 patients (31.7%). The indication for shunt ligation was an impossible postoperative approach (10 patients; 50%) or poor intraoperative hepatopetal flow (10 patients; 50%). There was no significant difference in the 1- and 5-year overall survival rates between the ligation and non-ligation group (80%, 80% vs 76%, 55%, respectively, P=0.17). Of the 34 patients in the non-ligation group who could be observed for 6 months, 14 patients (48.3%) had a spontaneous regression of SSPS. Additionally, 5 patients who required postoperative IVR had a good clinical course. There was no graft failure or adverse events in the non-ligation group.
Unnecessary ligation could be avoided by using our criteria. When postoperative IVR is possible with sufficient intraoperative hepatopetal flow, SPSS do not always need to be ligated in LDLT.

Keywords: Ligation; Liver Transplantation; Patent Ductus Venosus; Radiology, Interventional

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358