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20 July 2022 : Original article  

[In Press] Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients

Anna Popova123ACDE, Aiga Vasiļvolfa134ABCDEF, Kārlis Rācenis12ACD, Renārs Erts5C, Baiba Šlisere2BC, Anna Jana Saulīte12EF, Ieva Ziedina ORCID logo14AB, Inese Folkmane13AB, Harijs Čerņevskis14DE, Juta Kroiča2ACDF, Aivars Pētersons14ACD, Viktorija Kuzema ORCID logo14ACDE

DOI: 10.12659/AOT.936751

Ann Transplant In Press; DOI: 10.12659/AOT.936751  

Available online: 2022-07-20, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods for different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) is an innovative biomarker that is elevated in cases of angiogenesis, inflammation, and kidney injury. However, there are limited data about the diagnostic role of LRG-1 in kidney transplant recipients. The aim of this study was to evaluate the association between serum LRG-1, urine LRG-1, and kidney transplant function and injury.
MATERIAL AND METHODS
We enrolled 35 kidney transplant recipients in the study. LRG-1 in the serum and urine was detected using ELISA. We evaluated the correlation of serum and urine LRG-1 with traditional serum and urine kidney injury markers.
RESULTS
A higher level of serum LRG-1 correlates with a higher level of urine LRG-1. Serum LRG-1 has a positive correlation with transplant age, serum urea, serum creatinine, serum cystatin C, proteinuria, and fractional excretion of sodium (FENa) and a negative correlation with hemoglobin and estimated glomerular filtration rate (eGFR). Urine LRG-1 has a positive correlation with serum cystatin C, proteinuria, and urine neutrophil gelatinase-associated lipocalin (NGAL).
CONCLUSIONS
Higher levels of serum and urine LRG-1 are associated with kidney transplant injury and functional deterioration. Thus, LRG-1 might be also as a biomarker for tubular dysfunction in patients after kidney transplantation.

Keywords: Kidney Function Tests; Kidney Transplantation; LRG1 Protein, Human

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Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients

Ann Transplant In Press; DOI: 10.12659/AOT.936751  

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358