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12 February 2024 : Original article  

[In Press] No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Living Donor Liver Transplantation

Geunhyeok Yang ORCID logo1BCDEF, Shin Hwang ORCID logo2ABCDEF, Chul-Soo Ahn ORCID logo2BCDE, Deok-Bog Moon ORCID logo2BCDE, Tae-Yong Ha ORCID logo2ABCDE, Gi-Won Song ORCID logo2BCDE, Dong-Hwan Jung ORCID logo2BCDE, Gil-Chun Park ORCID logo2BCDE, Young-In Yoon ORCID logo2BCDE, Woo-Hyoung Kang ORCID logo2BCDE, Sun-Hyung Joo ORCID logo1BCDE, Sung-Gyu Lee ORCID logo2BCDE

DOI: 10.12659/AOT.942767

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

Available online: 2024-02-12, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
The effects of a low graft-to-recipient weight ratio (GRWR) on the prognosis of patients with hepatocellular carcinoma (HCC) are unclear. The present study examined whether the GRWR had an impact on the rate of HCC recurrence following living donor liver transplantation (LDLT).
MATERIAL AND METHODS
This retrospective observational single-center study included 856 patients who underwent LDLT for HCC between January 2006 and December 2016 at Asan Medical Center and evaluated the association between GRWR and post-transplant tumor recurrence.
RESULTS
Of the 856 patients who underwent LDLT for HCC, 54 (6.3%), 272 (31.8%), 274 (32.0%), and 256 (29.9%) had GRWR <0.8%, 0.8-0.99%, 1.0-1.19%, and ≥1.2%, respectively. Analysis of all patients revealed that the disease-free survival (DFS; P=0.545) and overall survival (OS; P=0.313) rates were not different in these 4 groups. Subgroups analyses also showed that GRWR did not influence survival rates in patients within (DFS: P=0.398; OS: P=0.676) and beyond (DFS: P=0.602; OS: P=0.649) the Milan criteria, or in patients with α-fetoprotein–des-γ-carboxyprothrombin–tumor volume scores <5log (DFS: P=0.633; OS: p=0.285) and ≥5log (DFS: P=0.674; OS: P=0.906).
CONCLUSIONS
GRWR less than 0.8% did not demonstrate a noteworthy prognostic influence on the oncological results among patients who had undergone LDLT for HCC. High-volume multi-center studies are necessary to validate these findings.

Keywords: Liver Neoplasms; Liver Transplantation; Living Donors; Neoplasm Recurrence, Local; Patient Selection

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358