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06 May 2025 : Original article  

[In Press] Post-Liver Transplantation Atrial Fibrillation: Insights into Clinical and ECG Predictors

Özge Çetinarslan ORCID logo1ABCDEF, Sinan Efe Yazıcı ORCID logo2ADF, Ahmet Atasever ORCID logo2ADF, Fatih Mehmet Uçar1ADEF

DOI: 10.12659/AOT.948243

Ann Transplant In Press; DOI: 10.12659/AOT.948243  

Available online: 2025-05-06, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
Liver transplant (LT) recipients have an increased risk for the development of postoperative atrial fibrillation (POAF). POAF has been associated with serious long-term outcomes such as thromboembolic events, stroke, heart failure, and even graft instability.
MATERIAL AND METHODS
We assessed potential clinical, biochemical, and ECG predictors of POAF in LT recipients between 2012 and 2024.The patients were divided into 2 groups: POAF and non-POAF (34.5%, n: 38 and 65.4, n: 72, respectively).
RESULTS
Basal characteristics and comorbidities of the 2 groups were similar. Patients in the POAF group had significantly higher heart rates (81.16±18.62 bpm vs 65.11±12.47 bpm, P<0.01) and longer maximal P-wave durations (169.47±20.41ms vs 145.06±33.99 ms, P<0.01). Maximal P-wave duration, PR interval, P-wave peak time in lead II (PWPT-II), QRS duration, and QTc interval were also significantly longer in the POAF group compared to the non-POAF group. With these consistent findings, we may consider that changes or abnormalities in P-wave indices are significant indicators of atrial conduction delay, even before the development of LA enlargement.
CONCLUSIONS
Our results are valuable in providing the prediction of POAF, which may be associated with major adverse outcomes such as mortality in LT recipients, using a simple and inexpensive tool like ECG. Such risks can be minimized by strategies such as optimization of beta-blocker therapy, fluid and electrolyte balance, and intraoperative temperature regulation.

Keywords: Atrial Fibrillation; Electrocardiography

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Post-Liver Transplantation Atrial Fibrillation: Insights into Clinical and ECG Predictors

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358