Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis

Zeping Gui; Wencheng Li; Shuang Fei; Miao Guo; Hao Chen; Li Sun; Zhijian Han; Jun Tao; Xiaobin Ju; Haiwei Yang; Ji-Fu Wei; Ruoyun Tan; Min Gu

doi:10.12659/AOT.917767

04 October 2019 : Original article

Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis

Zeping Gui^{ABCDEF 1}, Wencheng Li^{AB 2}, Shuang Fei^{CD 1}, Miao Guo^{CD 3}, Hao Chen^{CD 1}, Li Sun^{CD 1}, Zhijian Han^{CD 1}, Jun Tao^{CD 1}, Xiaobin Ju^{CD 1}, Haiwei Yang^{CD 1}, Ji-Fu Wei^{CD 3}, Ruoyun Tan^{CDFG 1*}, Min Gu^{CDG 1}

DOI: 10.12659/AOT.917767

Ann Transplant 2019; 24:553-568

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Supplementary Table 1. Detailed information of SNP detected in the Ubiquitin-related genes in the cohort.

Chromosome	Location	Reference allele	Alternation allele	Gene name	Function	Gene detail	Avsnp144
chr5	135272403	A	C	FBXL21	Exonic		rs573196792
chr5	135272692	C	T	FBXL21	Intronic		rs150784167
chr5	135272823	G	A	FBXL21	Intronic		rs17702049
chr5	135273078	C	A	FBXL21	Intronic		rs544746984
chr5	135273177	T	C	FBXL21	Exonic		.
chr5	135273298	C	A	FBXL21	Intronic		rs183239904
chr5	135273370	G	T	FBXL21	Intronic		rs10052673
chr5	135276049	G	A	FBXL21	Intronic		rs31549
chr5	135276205	G	C	FBXL21	Exonic		rs76075237
chr5	135276314	C	T	FBXL21	Exonic		rs40986
chr5	135276701	T	C	FBXL21	Intronic		rs31548
chr5	135276814	G	A	FBXL21	Exonic		rs2066913
chr5	135276847	T	C	FBXL21	Exonic		rs31547
chr5	135277204	C	G	FBXL21	Exonic		rs530876112
chr15	68346778	T	G	PIAS1	Intronic		.
chr15	68346778	T	C	PIAS1	Intronic		rs537399079
chr15	68348207	C	T	PIAS1	Intronic		.
chr15	68349843	C	G	PIAS1	Intronic		rs182709174
chr15	68349893	A	G	PIAS1	Intronic		rs1489598
chr15	68349918	T	C	PIAS1	Intronic		rs79833223
chr15	68349925	G	A	PIAS1	Intronic		rs183625509
chr15	68378937	G	A	PIAS1	Exonic	.PIAS1: NM_016166: exon2: c.G318A: p.S106S	rs145053928
chr15	68379138	C	T	PIAS1	Intronic		rs186753486
chr15	68434378	C	T	PIAS1	Splicing	NM_016166: exon3: c.554+10C>T.	rs750502048
chr15	68434379	G	C	PIAS1	Intronic		rs117588299
chr15	68434428	A	G	PIAS1	Intronic		.
chr15	68434744	G	A	PIAS1	Intronic		rs145280358
chr15	68439101	A	G	PIAS1	Intronic		rs576273919
chr15	68445850	C	G	PIAS1	Intronic		.
chr15	68445912	T	A	PIAS1	Intronic		rs11633620
chr15	68468049	C	T	PIAS1	Exonic	.PIAS1: NM_016166: exon10: c.C1244T: p.P415L	.
chr15	68468098	A	G	PIAS1	Exonic	.PIAS1: NM_016166: exon10: c.A1293G: p.G431G	rs113555272
chr15	68468136	C	T	PIAS1	Intronic		.
chr15	68468695	T	C	PIAS1	Intronic		rs12438361
chr15	68473443	T	C	PIAS1	Intronic		rs3759823
chr15	68473808	G	A	PIAS1	Intronic		rs75673552
chr15	68476069	A	G	PIAS1	Intronic		.
chr15	68479858	G	C	PIAS1	Intronic		.
chr15	68480086	A	G	PIAS1	Exonic	.PIAS1: NM_016166: exon14: c.A1869G: p.E623E	rs191408288
chr15	68480226	A	G	PIAS1	Utr3	NM_016166: c.53A>G.	rs372957210
chr18	44395368	T	C	PIAS2	Intronic		rs3737448
chr18	44398111	C	T	PIAS2	Utr3	NM_173206: c.229G>A.	rs10502879
chr18	44398183	A	T	PIAS2	Utr3	NM_173206: c.157T>A.	.
chr18	44398464	G	A	PIAS2	Intronic		rs149740503
chr18	44398557	A	T	PIAS2	Intronic		rs183321210
chr18	44401052	G	A	PIAS2	Intronic		rs146442641
chr18	44407993	G	A	PIAS2	Exonic	.PIAS2: NM_004671: exon11: c.C1437T: p.D479D,PIAS2: NM_173206: exon11: c.C1437T: p.D479D	rs35451178
chr18	44409581	C	A	PIAS2	Intronic		rs72907142
chr18	44409617	G	A	PIAS2	Intronic		.
chr18	44416287	G	A	PIAS2	Intronic		.
chr18	44416608	C	T	PIAS2	Intronic		rs72907148
chr18	44423925	A	G	PIAS2	Intronic		rs77040088
chr18	44424122	A	G	PIAS2	Intronic		rs188584114
chr18	44424939	G	A	PIAS2	Intronic		rs372024400
chr18	44424995	A	G	PIAS2	Intronic		rs150885589
chr18	44426800	T	C	PIAS2	Exonic	.PIAS2: NM_004671: exon6: c.A731G: p.Y244C,PIAS2: NM_173206: exon6: c.A731G: p.Y244C	rs114135676
chr18	44426877	C	T	PIAS2	Intronic		rs644731
chr18	44435407	A	G	PIAS2	Splicing	NM_004671: exon6: c.636-9T>C;NM_173206: exon6: c.636-9T>C.	rs764656048
chr18	44470481	T	C	PIAS2	Intronic		rs539782995
chr18	44470706	G	A	PIAS2	Exonic	.PIAS2: NM_004671: exon2: c.C336T: p.H112H,PIAS2: NM_173206: exon2: c.C336T: p.H112H	rs113887072
chr18	44470825	A	G	PIAS2	Exonic	.PIAS2: NM_004671: exon2: c.T217C: p.S73P,PIAS2: NM_173206: exon2: c.T217C: p.S73P	.
chr18	44483961	T	C	PIAS2	Intronic		rs72915074
chr18	44496847	C	T	PIAS2	Intronic		rs567309045
chr18	44497099	C	A	PIAS2	Intronic		rs530227612
chr18	44497124	C	T	PIAS2	Intronic		.
chr18	44497173	C	A	PIAS2	Intronic		.
chr18	44497338	T	G	PIAS2	Utr5	NM_004671: c.-30A>C;NM_173206: c.-30A>C.	.
chr2	203072108	G	A	SUMO1	Intronic		.
chr2	203072889	T	C	SUMO1	Intronic		.
chr2	203079307	T	C	SUMO1	Intronic		rs3769817
chr2	203096545	C	A	SUMO1	Intronic		rs116081766
chr2	203103241	G	T	SUMO1	Utr5	NM_001005781: c.-67C>A;NM_001005782: c.-67C>A;NM_003352: c.-67C>A.	.
chr17	73177444	C	A	SUMO2	Intronic		rs1471453
chr17	73179065	C	G	SUMO2	Utr5	NM_001005849: c.-136G>C;NM_006937: c.-136G>C.	.
chr21	46226786	A	G	SUMO3	Utr3	NM_001286416: c.80T>C;NM_006936: c.80T>C.	rs1051331
chr21	46227163	A	G	SUMO3	Intronic		rs2329902
chr21	46227968	T	G	SUMO3	Intronic		.
chr21	46228150	G	A	SUMO3	Intronic		.
chr21	46228153	C	T	SUMO3	Intronic		.
chr21	46228154	G	A	SUMO3	Intronic		rs752652207
chr21	46228155	C	T	SUMO3	intronic		rs757331290
chr21	46228157	T	G	SUMO3	Intronic		rs765382230
chr21	46228165	T	C	SUMO3	Intronic		rs7283639
chr21	46228170	T	G	SUMO3	Intronic		rs188978703
chr21	46228243	T	C	SUMO3	Intronic		rs141141907
chr21	46228662	C	T	SUMO3	Intronic		.
chr21	46228930	C	T	SUMO3	Intronic		rs235293
chr21	46228945	C	T	SUMO3	Intronic		rs564735586
chr21	46228949	G	C	SUMO3	Intronic		.
chr21	46233836	C	A	SUMO3	Exonic	.SUMO3: NM_001286416: exon2: c.G205T: p.V69F	rs2838697
chr21	46233863	G	C	SUMO3	Exonic	.SUMO3: NM_001286416: exon2: c.C178G: p.L60V	rs13050872
chr21	46233866	T	C	SUMO3	Exonic	.SUMO3: NM_001286416: exon2: c.A175G: p.S59G	rs9981327
chr21	46234079	T	A	SUMO3	Intronic	..	rs9306116
chr6	149721690	G	A	SUMO4	Exonic	.SUMO4: NM_001002255: exon1: c.G163A: p.V55M	rs237025
chr6	149721778	T	C	SUMO4	Exonic	.SUMO4: NM_001002255: exon1: c.T251C: p.I84T	rs777445425
chr6	149721800	G	A	SUMO4	Exonic	.SUMO4: NM_001002255: exon1: c.G273A: p.T91T	rs145312495
chr6	149721965	T	C	SUMO4	Utr3	NM_001002255: c.150T>C.	rs237024
chr6	149722040	A	G	SUMO4	Utr3	NM_001002255: c.225A>G.	rs237023
chr10	60095105	G	T	UBE2D1	Intronic		rs112660736
chr10	60121139	A	G	UBE2D1	Exonic	.UBE2D1: NM_003338: exon2: c.A66G: p.S22S	rs759280904
chr10	60121240	C	T	UBE2D1	Intronic		.
chr10	60123486	A	G	UBE2D1	Intronic		rs73288305
chr10	60123523	A	G	UBE2D1	Intronic		.
chr10	60124703	C	T	UBE2D1	Intronic		.
chr10	60127627	A	G	UBE2D1	Intronic		rs531786752
chr10	60127639	G	T	UBE2D1	Intronic		rs74377516
chr10	60127798	T	C	UBE2D1	Intronic		.
chr10	60127838	G	A	UBE2D1	Intronic		rs75362994
chr10	60128364	T	C	UBE2D1	Intronic		rs3802699
chr10	60128583	A	G	UBE2D1	Utr3	NM_001204880: c.58A>G;NM_003338: c.58A>G.	rs148198083
chr16	1363878	C	T	UBE2I	Intronic		rs9926183
chr16	1363927	A	G	UBE2I	Intronic		.
chr16	1364140	T	C	UBE2I	Intronic		rs9941160
chr16	1364158	G	A	UBE2I	Intronic		.
chr16	1364251	C	T	UBE2I	Intronic		rs201695180
chr16	1364281	T	C	UBE2I	Intronic		rs4984806
chr16	1364365	A	G	UBE2I	Exonic	.UBE2I: NM_003345: exon3: c.A138G: p.P46P,UBE2I: NM_194260: exon3: c.A138G: p.P46P,UBE2I: NM_194261: exon3: c.A138G: p.P46P,UBE2I: NM_194259: exon4: c.A138G: p.P46P	rs4610
chr16	1365612	G	A	UBE2I	Intronic		rs781398317
chr16	1365915	C	T	UBE2I	Intronic		rs112302601
chr16	1365935	C	G	UBE2I	Intronic		rs4984807
chr16	1365943	C	T	UBE2I	Intronic		rs7186045
chr16	1365967	C	T	UBE2I	Intronic		rs4984808
chr16	1369612	C	T	UBE2I	Intronic		rs201661304
chr16	1369730	A	G	UBE2I	Intronic		rs9933497
chr16	1369837	C	T	UBE2I	Intronic		.
chr16	1369926	T	C	UBE2I	Intronic		rs909915
chr16	1370203	G	A	UBE2I	Exonic	.UBE2I: NM_003345: exon5: c.G252A: p.P84P,UBE2I: NM_194260: exon5: c.G252A: p.P84P,UBE2I: NM_194261: exon5: c.G252A: p.P84P,UBE2I: NM_194259: exon6: c.G252A: p.P84P	rs758216436
chr16	1370303	T	C	UBE2I	Intronic		rs909916
chr16	1370309	C	G	UBE2I	Intronic		rs909917
chr16	1370383	C	T	UBE2I	Intronic		rs148789348
chr16	1370575	G	C	UBE2I	Intronic		.
chr16	1370597	G	C	UBE2I	Intronic		rs4017786
chr16	1370614	C	G	UBE2I	Intronic		rs8063770
chr16	1370630	A	G	UBE2I	Intronic		rs8043720
chr16	1370682	G	A	UBE2I	Intronic		rs79005361
chr16	1370698	G	A	UBE2I	Intronic		rs571836605
chr16	1370716	C	T	UBE2I	Intronic		rs142273742
chr16	1370729	C	A	UBE2I	Intronic		rs909918
chr16	1374513	G	A	UBE2I	Intronic		rs2369700
chr16	1374524	A	G	UBE2I	Intronic		rs761059
chr16	1374629	G	T	UBE2I	Intronic		.
chr16	1374656	A	G	UBE2I	Intronic		rs761060
chr16	1374785	G	A	UBE2I	Exonic	.UBE2I: NM_003345: exon7: c.G468A: p.A156A,UBE2I: NM_194260: exon7: c.G468A: p.A156A,UBE2I: NM_194261: exon7: c.G468A: p.A156A,UBE2I: NM_194259: exon8: c.G468A: p.A156A	rs762904858
chr16	1374818	A	G	UBE2I	UTR3	NM_003345: c.24A>G;NM_194259: c.24A>G;NM_194260: c.24A>G;NM_194261: c.24A>G.	rs8063
SNP – single nuclear polymorphism.

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Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis

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