23 June 2020 : Original article
Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation
Weiguo Sui1A, Qing Gan1CE, Fuhua Liu1B, Minglin Ou1D, Bingguo Wang1F, Songbai Liao1F, Liusheng Lai1F, Huaizhou Chen1D, Ming Yang1G*, Yong Dai2AGDOI: 10.12659/AOT.921844
Ann Transplant 2020; 25:e921844
Table 2 Potential metabolite makers of negative ions from Pre vs. NC.
Metabolite name | m/z | Change | VIP | Fold change | q-value | Related pathway |
---|---|---|---|---|---|---|
Threonic acid | 135.0296 | ↑ | 2.920519 | 6.722945 | 0.002249 | Ascorbate and aldarate metabolism |
Threonic acid | 135.0299 | ↑ | 3.101811 | 8.680666 | 0.002504 | Ascorbate and aldarate metabolism |
Phosphoribosyl formamidocarboxamide | 365.0538 | ↑ | 1.429341 | 1.667861 | 0.015919 | Purine metabolism; Metabolic pathways; Biosynthesis of secondary metabolites |
8(R)-Hydroperoxylinoleic acid | 311.2199 | ↑ | 1.985069 | 3.354787 | 0.049389 | Linoleic acid metabolism |
13-L-Hydroperoxylinoleic acid | 311.2199 | ↑ | 1.985069 | 3.354787 | 0.049389 | Linoleic acid metabolism; Metabolic pathways |
9(S)-HPODE | 311.2199 | ↑ | 1.985069 | 3.354787 | 0.049389 | Linoleic acid metabolism; Metabolic pathways |
Taurocholic acid | 514.2828 | ↑ | 3.725514 | 121.6349 | 0.025012 | Primary bile acid biosynthesis; Secondary bile acid biosynthesis; Taurine and hypotaurine metabolism; Metabolic pathways; Bile secretion |
8-HETE | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways; PPAR signaling pathway |
8,9-Epoxyeicosatrienoic acid | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways; Vascular smooth muscle contraction |
19(S)-HETE | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways |
11(R)-HETE | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism |
15(S)-HETE | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism |
20-Hydroxyeicosatetraenoic acid | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways; Vascular smooth muscle contraction |
5,6-Epoxy-8,11,14-eicosatrienoic acid | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways; Vascular smooth muscle contraction |
16(R)-HETE | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism |
14,15-Epoxy-5,8,11-eicosatrienoic acid | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways; Vascular smooth muscle contraction |
11,12-Epoxyeicosatrienoic acid | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism; Metabolic pathways; Vascular smooth muscle contraction |
5-HETE | 319.2261 | ↓ | 3.539139 | 0.104499 | 0.007557 | Arachidonic acid metabolism |
Docosapentaenoic acid | 329.2469 | ↓ | 1.976434 | 0.413162 | 0.008974 | Biosynthesis of unsaturated fatty acids |
Arachidonic acid | 303.2320 | ↓ | 2.263972 | 0.331697 | 0.000831 | Arachidonic acid metabolism; Linoleic acid metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Vascular smooth muscle contraction; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Long-term depression; Phototransduction – fly; GnRH signaling pathway; Leishmaniasis; Amoebiasis |
Taurochenodeoxycholic acid | 498.2879 | ↑ | 2.958113 | 33.07833 | 0.044239 | Primary bile acid biosynthesis; Secondary bile acid biosynthesis; Bile secretion |
9,10-Epoxyoctadecenoic acid | 295.2257 | ↓ | 1.591986 | 0.55364 | 0.02713 | Linoleic acid metabolism; Metabolic pathways |
Alpha-dimorphecolic acid | 295.2257 | ↓ | 1.591986 | 0.55364 | 0.02713 | Linoleic acid metabolism; PPAR signaling pathway |
12,13-EpOME | 295.2257 | ↓ | 1.591986 | 0.55364 | 0.02713 | Linoleic acid metabolism; Metabolic pathways |
13S-hydroxyoctadecadienoic acid | 295.2257 | ↓ | 1.591986 | 0.55364 | 0.02713 | Linoleic acid metabolism; PPAR signaling pathway |
Chenodeoxycholic acid glycine conjugate | 448.3056 | ↑ | 2.59988 | 6.271501 | 0.010639 | Primary bile acid biosynthesis; Secondary bile acid biosynthesis; Bile secretion |
Glycocholic acid | 464.3005 | ↑ | 2.925803 | 9.113965 | 0.015133 | Primary bile acid biosynthesis; Secondary bile acid biosynthesis; Metabolic pathways; Bile secretion |
9,12,13-TriHOME | 329.2304 | ↑ | 2.3531 | 3.288932 | 0.006036 | Linoleic acid metabolism |
9,10,13-TriHOME | 329.2304 | ↑ | 2.3531 | 3.288932 | 0.006036 | Linoleic acid metabolism |
Adipate semialdehyde | 129.0544 | ↓ | 1.13189 | 0.720488 | 0.025688 | Caprolactam degradation; Metabolic pathways; Microbial metabolism in diverse environments |
Ketoleucine | 129.0544 | ↓ | 1.13189 | 0.720488 | 0.025688 | Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Glucosinolate biosynthesis; Metabolic pathways; Biosynthesis of secondary metabolites |
Phosphoribosyl formamidocarboxamide | 401.0251 | ↑ | 1.649845 | 1.751775 | 0.003328 | Purine metabolism; Metabolic pathways; Biosynthesis of secondary metabolites |
Trans-Cinnamic acid | 147.0438 | ↑ | 1.2355 | 1.388167 | 0.001396 | Phenylalanine metabolism; Phenylpropanoid biosynthesis; Metabolic pathways; Biosynthesis of secondary metabolites; Microbial metabolism in diverse environments |
The markers were chosen on the basis of VIP from the OPLS-DA greater than 1.0, q-value |