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14 July 2020 : Original article  

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats

Shinichi Nakanuma1ABCDEFG*, Hidehiro Tajima1AC, Hiroyuki Takamura1ACG, Seisho Sakai1A, Ryosuke Gabata1B, Mitsuyoshi Okazaki1B, Hiroyuki Shinbashi1B, Yoshinao Ohbatake1B, Isamu Makino1B, Hironori Hayashi2A, Tomoharu Miyashita1AC, Sachio Fushida1A, Tetsuo Ohta1ACE

DOI: 10.12659/AOT.922306

Ann Transplant 2020; 25:e922306

Table 1 Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T-Bil), direct bilirubin (D-Bil), lactate dehydrogenase (LDH), hyaluronic acid (HA) levels, and platelet counts 5 h after reperfusion: Serum AST, ALT, T-Bil, D-Bil, LDH, and HA were significantly elevated in the ischemia-reperfusion (IR) group compared with those of the sham group. Serum AST and D-Bil levels were significantly lower in the IR+milrinone group than in the IR group. Platelet counts were significantly decreased in the IR group as compared with those of the sham group. Platelet counts were significantly higher in the IR+milrinone group than in the IR group.

VariableShamIRIR+milrinone
AST (IU/L)144±211271±640** 749±291#
ALT (IU/L)33±6764±504** 471±211
T-Bil (mg/dL)0.033±0.0070.114±0.045** 0.086±0.019
D-Bil (mg/dL)0.016±0.0060.077±0.015** 0.061±0.007##
LDH (IU/L)492±1912289±2535* 876±679
Hyaluronic acid (ng/dL)33.9±7.951.9±14.4** 49.9±14.9
Platelets (10/μL)101.1±9.788.1±17.7* 103.4±12.3#
* Significantly (
** Significantly (
# Significantly (
## Significantly (

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358