22 September 2020: Original Paper
Intensive Doppler Ultrasonography for Early Detection of Hepatic Artery Thrombosis After Adult Living Donor Liver Transplantation
Pi-Ling Chiang 1ABCDEF , Yu-Fan Cheng 1ADG , Tung-Liang Huang 1BG , Hsin-You Ou 1B , Chun-Yen Yu 1B , Hsien-Wen Hsu 1B , Wei-Xiong Lim 1B , Chao-Long Chen 2B , Chee-Chien Yong 2B , Leo Leung-Chit Tsang 1ABDEF*DOI: 10.12659/AOT.924336
Ann Transplant 2020; 25:e924336
Table 1 The demographic and clinical characteristics of adult LDLT recipients with abnormal Doppler flows in different treatment groups.
| Medical group (n=5) | Surgical group (n=4) | |||||
|---|---|---|---|---|---|---|
| n | Mean±SD | Range | n | Mean±SD | Range | |
| Gender | ||||||
| Male | 5 | 2 | ||||
| Female | 0 | 2 | ||||
| Age (years) | 55.6±11.1 | 38–66 | 55.0±9.2 | 43–65 | ||
| Time of diagnosis of HAT (POD) | 9.2±5.3 | 3–14 | 7.8±4.8 | 1–12 | ||
| Serum AST (U/L) | 56.80±11.88 | 40–72 | 201.50±242.21 | 34–548 | ||
| Serum ALT (U/L) | 137.20±64.61 | 86–250 | 285.00±326.00 | 57–752 | ||
| Serum TB (mg/dL) | 1.56±0.72 | 0.7–2.3 | 2.45±1.75 | 0.6–4.7 | ||
| Serum DB (mg/dL) | 0.61±0.42 | 0.3–1.1 | 0.85±0.54 | 0.3–1.6 | ||
| Post-LDLT Doppler US of HA | ||||||
| Doppler US waveform | 5 | 4 | ||||
| Complete absence | 2 | 2 | ||||
| Tardus parvus | 3 | 2 | ||||
| PSV (cm/second) | 21.83±13.77 | 10.1–37.0 | 28.75±4.17 | 25.8–31.7 | ||
| RI | 0.49±0.08 | 0.43–0.58 | 0.56±0.07 | 0.51–0.61 | ||
| CTA of intrahepatic HA | ||||||
| Patency | 1 | 0 | ||||
| Partial occlusion | 4 | 1 | ||||
| Total occlusion | 0 | 3 | ||||
| Time of discharge (POD) | 5 | 51.2±10.5 | 35–62 | 4 | 174.3±198.2 | 53–403 |
| Long-term follow-up | ||||||
| Mortality* | 0 | 1 | ||||
| Biliary dilatation | 0 | 1 | ||||
| Serum TB (mg/dL) | N/A | N/A | 7.5 | N/A | ||
| Serum DB (mg/dL) | N/A | N/A | 5.5 | N/A | ||
| No biliary complication | 5 | 2 | ||||
| Serum TB (mg/dL) | 0.56±0.23 | 0.3–0.8 | 0.60±0.42 | 0.3–0.9 | ||
| Serum DB (mg/dL) | 0.14±0.05 | 0.1–0.2 | 0.15±0.07 | 0.1–0.2 | ||
| * Mortality case due to internal bleeding and multiorgan failure. ALT – alanine transaminase; AST – aspartate transaminase; DB – direct bilirubin; HA – hepatic artery; HAT – hepatic artery thrombosis; LDLT – living donor liver transplantation; N/A – not applicable; POD – postoperative day; PSV – peak systolic velocity; RI – resistive index; TB – total bilirubin; US – ultrasonography. | ||||||