05 February 2021 : Original article
Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients
Senichiro Yanagawa1BCDEF, Hiroyuki Tahara1ADEFG*, Yuka Tanaka1B, Seiichi Shimizu1B, Masahiro Ohira1B, Kentaro Ide1B, Hideki Ohdan1DFGDOI: 10.12659/AOT.925475
Ann Transplant 2021; 26:e925475
Table 4 There were no significant differences between the groups with and without osteoporosis in bone metabolism marker abnormalities, sex, presence or absence of menopause, body mass index, hepatitis C virus-related disease, or duration of administration of steroids or diuretics. A difference was found in the incidence of fragility fracture due to osteoporosis only in the patients with alcoholic liver cirrhosis.
| With osteoporosisn=17 | Without isteoporosisn=28 | p Value | |
|---|---|---|---|
| Incidence of fragility fracture (%) | 88.2 | 14.3 | <0.001 |
| Age | 56.6±9.2 | 56.2±11.6 | 0.919 |
| Postmenopausal women (%) | 29.4 | 50.0 | 0.175 |
| Preoperative Ca (mg/dl) | 9.5±1.0 | 9.4±0.6 | 0.609 |
| Preoperative P (mg/dl) | 3.6±0.8 | 3.2±0.7 | 0.178 |
| Preoperative iPTH (pg/ml) | 74.2±60.5 | 54.7±49.3 | 0.563 |
| BMI (kg/m) | 23.7±3.7 | 22.5±3.2 | 0.28 |
| Duration of steroid therapy after transplantation (month) | 19.9±29.2 | 18.6±13.8 | 0.843 |
| Liver cirrhosis(HCV) (%) | 35.3 | 25.0 | 0.46 |
| Liver cirrhosis (alcohol) (%) | 23.5 | 3.8 | 0.039 |
| Diuretics (more than 1 month postoperation) (%) | 58.8 | 46.4 | 0.42 |
| DM (%) | 17.6 | 3.8 | 0.108 |
| Ca – calcium; P – Phosphorus; iPTH – intact parathyroid hormone; BMI – body mass index; HCV – hepatitis C virus; DM – diabetes mellitus. | |||