05 February 2021 : Original article
Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients
Senichiro Yanagawa1BCDEF, Hiroyuki Tahara1ADEFG*, Yuka Tanaka1B, Seiichi Shimizu1B, Masahiro Ohira1B, Kentaro Ide1B, Hideki Ohdan1DFGDOI: 10.12659/AOT.925475
Ann Transplant 2021; 26:e925475
Table 5 There were no significant differences between the groups with and without fragility fractures in bone metabolism marker abnormalities, sex, presence or absence of menopause, body mass index, hepatitis C virus-related disease, alcohol-related disease, or duration of administration of steroids or diuretics.
| With fracturen=19 | Without fracturen=26 | p Value | |
|---|---|---|---|
| Incidence of osteoporosis (%) | 78.9 | 7.7 | <0.001 |
| Age | 55.8±10.2 | 56.7±11.2 | 0.771 |
| Postmenopausal women (%) | 26.3 | 53.8 | 0.065 |
| Preoperative Ca (mg/dl) | 9.4±0.9 | 9.4±0.6 | 0.95 |
| Preoperative P (mg/dl) | 3.2±0.9 | 3.4±0.5 | 0.274 |
| Preoperative iPTH (pg/ml) | 73.7±64.1 | 43.8±17.7 | 0.337 |
| BMI (kg/m) | 23.3±3.9 | 22.7±3.1 | 0.591 |
| Duration of steroid therapy after transplantation (month) | 21.6±25.4 | 17.1±21.1 | 0.519 |
| Liver cirrhosis(HCV) (%) | 26.3 | 30.8 | 0.745 |
| Liver cirrhosis (alcohol) (%) | 21.1 | 3.8 | 0.07 |
| Diuretics (more than 1 month postoperation) (%) | 73.7 | 53.8 | 0.68 |
| DM (%) | 10.5 | 7.7 | 0.741 |
| Ca – calcium; P – Phosphorus; iPTH – intact parathyroid hormone; BMI – body mass index; HCV – hepatitis C virus; DM – diabetes mellitus. | |||