06 October 2020 : Original article
Acute Rejection and Infectious Complications in ABO- and HLA-Incompatible Kidney Transplantations
Youngmin Ko1BCDE, Jee Yeon Kim1BCDE, Sung-Han Kim2ADEF, Dong Hyun Kim1B, Seong Jun Lim1B, Sung Shin1CD, Young Hoon Kim1BCD, Joo Hee Jung1BC, Su-Kil Park3DE, Hyunwook Kwon1ABCDEF*, Duck Jong Han1ADFDOI: 10.12659/AOT.927420
Ann Transplant 2020; 25:e927420
Table 2 Infection prior to rejection.
| Variables | ABOc & HLAc (N=1190) | ABOc & HLAi* (N=131) | ABOi & HLAc (N=358) | ABOi & HLAi* (N=53) | p-Value |
|---|---|---|---|---|---|
| BK viremia positive | 294 (24.7) | 23 (17.6) | 95 (26.5) | 14 (26.4) | 0.23 |
| BK viremia PCR ≥4 logs | 102 (8.6) | 10 (7.6) | 84 (23.5) | 13 (24.5) | <0.01 |
| CMV viremia positive | 443 (37.2) | 67 (51.1) | 129 (36.0) | 27 (50.9) | <0.01 |
| CMV viremia PCR ≥4 logs | 106 (8.9) | 16 (12.2) | 18 (5.0) | 6 (11.3) | 0.03 |
| Urinary tract infection | 133 (11.2) | 25 (19.1) | 29 (8.1) | 11 (20.8) | <0.01 |
| Pneumonia | 65 (5.5) | 9 (6.9) | 20 (5.6) | 4 (7.5) | 0.75 |
| Combined infection** | 318 (26.7) | 43 (32.8) | 127 (35.5) | 25 (47.2) | <0.01 |
| Mortality due to infection | 7 (0.6) | 1 (0.8) | 3 (0.8) | 4 (7.5) | <0.01 |
| Categorical variables are presented as counts and percentages. ABOc – ABO-compatible; ABOi – ABO-incompatible; HLA – human leukocyte antigen; CMV – cytomegalovirus. * HLA-incompatible kidney transplantation was defined as CDC XM, FCXM-positive, and/or maximal DSA MFI ≥500; ** Combined infection consisted of BK viremia PCR ≥4 logs, CMV viremia PCR ≥4 logs, urinary tract infection, and pneumonia. | |||||