06 October 2020 : Original article
Acute Rejection and Infectious Complications in ABO- and HLA-Incompatible Kidney Transplantations
Youngmin Ko1BCDE, Jee Yeon Kim1BCDE, Sung-Han Kim2ADEF, Dong Hyun Kim1B, Seong Jun Lim1B, Sung Shin1CD, Young Hoon Kim1BCD, Joo Hee Jung1BC, Su-Kil Park3DE, Hyunwook Kwon1ABCDEF*, Duck Jong Han1ADFDOI: 10.12659/AOT.927420
Ann Transplant 2020; 25:e927420
Table 4 Factors associated with the occurrence of acute rejection.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Female ( Male) | 1.05 (0.76–1.45) | 0.76 | NA | NA |
| Cyclosporin ( tacrolimus) | 1.22 (0.87–1.70) | 0.25 | NA | NA |
| PP number | 1.09 (1.04–1.14) | <0.01 | 1.01 (0.94–1.08) | 0.83 |
| Rituximab dose=0 mg | Reference | |||
| 100–299 mg | 1.22 (0.91–1.65) | 0.19 | NA | NA |
| 300–500 mg | 1.36 (0.93–1.98) | 0.11 | NA | NA |
| BK viremia PCR ≥4 logs | 1.54 (1.23–1.94) | <0.01 | NA | NA |
| CMV viremia PCR ≥4 logs | 1.81 (1.46–2.24) | <0.01 | NA | NA |
| Urinary tract infection | 1.25 (0.92–1.69) | 0.16 | NA | NA |
| Pneumonia | 2.00 (1.41–2.86) | <0.01 | NA | NA |
| Combined infection* | 1.89 (1.47–2.43) | <0.01 | 1.91 (1.45–2.51) | <0.01 |
| ABOc & HLAc | Reference | |||
| ABOc & HLAi | 1.29 (0.87–1.90) | 0.20 | 1.90 (0.79–4.57) | 0.15 |
| ABOi & HLAc | 1.22 (0.89–1.66) | 0.22 | 1.22 (0.83–1.78) | 1.22 |
| ABOi & HLAi | 1.93 (1.05–3.55) | 0.34 | 2.63 (1.04–6.65) | 0.04 |
| HLA-compatible | Reference | |||
| CDC-positive | 3.13 (1.61–6.09) | <0.01 | 1.25 (0.39–4.04) | 0.71 |
| FCXM-positive | 1.08 (0.72–1.63) | 0.72 | 0.52 (0.21–1.34) | 0.52 |
| PP – plasmapheresis; CMV – cytomegalovirus; ABOc – ABO-compatible; ABOi – ABO-incompatible; HLA – human leukocyte antigen; CDC – complement-dependent cytotoxicity; FCXM – flow-cytometric crossmatch; DSA – donor-specific antibody. * Combined infection consisted of BK viremia PCR ≥4 logs, CMV viremia PCR ≥4 logs, urinary tract infection, and pneumonia. | ||||