09 February 2021 : Original article
Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation
Kumiko Muta1ABCDEF*, Mineaki Kitamura1ABCDE, Masaaki Hidaka2BE, Yuki Ota1AB, Takanobu Hara2BE, Akihiko Soyama2BD, Satoshi Miuma3BE, Hisamitsu Miyaaki3BE, Kazuhiko Nakao3BE, Susumu Eguchi2BDE, Hiroshi Mukae4DE, Tomoya Nishino1ADEDOI: 10.12659/AOT.928858
Ann Transplant 2021; 26:e928858
Table 1 Patient baseline characteristics.
| Age (years old) | 53.8±11.5 |
| Sex, Male (n (%)) | 108 (56.5) |
| Height (m) | 1.62±0.09 |
| Weight (kg) | 63.7±13.4 |
| Cirrhosis to HBV (n (%)) | 34 (17.8) |
| Cirrhosis to HCV (n (%)) | 69 (36.1) |
| Cirrhosis to alcohol (n (%)) | 28 (14.7) |
| MELD score | 18.0±7.6 |
| Pretransplant diabetes mellitus (n (%)) | 43 (22.5) |
| Pretransplant hypertension (n (%)) | 29 (15.1) |
| Pretransplant proteinuria >(1+) (n (%)) | 16 (9.0) |
| Pretransplant hemoglobin (g/dL) | 10.5±2.3 |
| Pretransplant albumin (g/dL) | 3.0±0.6 |
| Pretransplant total bilirubin (mg/dL)* | 3.4 (1.8–7.7)* |
| Pretransplant eGFR (mL/min/1.73 m) | 76.1±30.9 |
| Intra-operative hemorrhage (mL)* | 5800 (3600–11000)* |
| Calcineurin inhibitor (n (%)) | 169 (88.5) |
| Tacrolimus (n (%)) | 153 (80.1) |
| Cyclosporine (n (%)) | 16 (8.4) |
| Steroid (n (%)) | 31 (16.2) |
| Mycophenolate mofetil | 114 (59.7) |
| Data are expressed as the mean±standard deviation or the median value (quartile). * Shows the median value (quartile). eGFR – estimated glomerular filtration rate; HBV – hepatitis B virus; HCV – hepatitis C virus; MELD – model for end-stage liver disease. | |