09 February 2021 : Original article
Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation
Kumiko Muta1ABCDEF*, Mineaki Kitamura1ABCDE, Masaaki Hidaka2BE, Yuki Ota1AB, Takanobu Hara2BE, Akihiko Soyama2BD, Satoshi Miuma3BE, Hisamitsu Miyaaki3BE, Kazuhiko Nakao3BE, Susumu Eguchi2BDE, Hiroshi Mukae4DE, Tomoya Nishino1ADEDOI: 10.12659/AOT.928858
Ann Transplant 2021; 26:e928858
Table 2 The comparison between the ameliorating and deteriorating group of eGFR change over 1 year after living donor liver transplantation.
| Ameliorating group (N=65) | Deteriorating group (N=126) | p Value | |
|---|---|---|---|
| Age (years old) | 53.8±11.4 | 53.9±11.7 | 0.95 |
| Sex, Male (%) | 47.7 | 61.1 | 0.08 |
| HCV antibody positive (%) | 38.5 | 34.1 | 0.63 |
| MELD score | 19.0±8.1 | 17.5±7.4 | 0.25 |
| Pretransplant diabetes mellitus (%) | 24.6 | 21.4 | 0.62 |
| Pretransplant hypertension (%) | 15.4 | 15.1 | 0.96 |
| Pretransplant diuretics (%) | 75.4 | 55.6 | 0.007 |
| Pretransplant proteinuria >(1+) (%) | 8.5 | 9.2 | 1.00 |
| Pretransplant hemoglobin (g/dL) | 9.8±2.0 | 10.9±2.4 | 0.009 |
| Pretransplant albumin (g/dL) | 2.9±0.6 | 3.0±0.6 | 0.09 |
| Pretransplant total bilirubin (mg/dL) | 3.4 (1.9–7.7)* | 3.4 (1.6–9.7)* | 0.74 |
| Pretransplant eGFR (mL/min/1.73 m) | 52.1±21.6 | 88.5±27.5 | <0.001 |
| Tacrolimus (%) | 81.3 | 80.2 | 0.86 |
| Cyclosporine (%) | 4.6 | 10.3 | 0.27 |
| Steroid (%) | 21.5 | 13.5 | 0.21 |
| Mycophenolate mofetil (%) | 67.6 | 55.6 | 0.11 |
| Trough value of tacrolimus 1 year after LDLT (ng/mL) (n=145) | 5.2±2.3 | 6.5±2.8 | 0.01 |
| Trough value of cyclosporine 1 year after LDLT (ng/mL) (n=26) | 130±64.3 | 156.6±62.5 | 0.40 |
| Data are expressed as the mean±standard deviation or the median value (quartile). * Shows the median value (quartile). eGFR – estimated glomerular filtration rate; HCV – hepatitis C virus; LDLT – living donor liver transplantation; MELD – model for end-stage liver disease. | |||