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09 February 2021 : Original article  

Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation

Kumiko Muta1ABCDEF*, Mineaki Kitamura1ABCDE, Masaaki Hidaka2BE, Yuki Ota1AB, Takanobu Hara2BE, Akihiko Soyama2BD, Satoshi Miuma3BE, Hisamitsu Miyaaki3BE, Kazuhiko Nakao3BE, Susumu Eguchi2BDE, Hiroshi Mukae4DE, Tomoya Nishino1ADE

DOI: 10.12659/AOT.928858

Ann Transplant 2021; 26:e928858

Table 2 The comparison between the ameliorating and deteriorating group of eGFR change over 1 year after living donor liver transplantation.

Ameliorating group (N=65)Deteriorating group (N=126)p Value
Age (years old)53.8±11.453.9±11.70.95
Sex, Male (%)47.761.10.08
HCV antibody positive (%)38.534.10.63
MELD score19.0±8.117.5±7.40.25
Pretransplant diabetes mellitus (%)24.621.40.62
Pretransplant hypertension (%)15.415.10.96
Pretransplant diuretics (%)75.455.60.007
Pretransplant proteinuria >(1+) (%)8.59.21.00
Pretransplant hemoglobin (g/dL)9.8±2.010.9±2.40.009
Pretransplant albumin (g/dL)2.9±0.63.0±0.60.09
Pretransplant total bilirubin (mg/dL)3.4 (1.9–7.7)* 3.4 (1.6–9.7)* 0.74
Pretransplant eGFR (mL/min/1.73 m)52.1±21.688.5±27.5
Tacrolimus (%)81.380.20.86
Cyclosporine (%)4.610.30.27
Steroid (%)21.513.50.21
Mycophenolate mofetil (%)67.655.60.11
Trough value of tacrolimus 1 year after LDLT (ng/mL) (n=145)5.2±2.36.5±2.80.01
Trough value of cyclosporine 1 year after LDLT (ng/mL) (n=26)130±64.3156.6±62.50.40
Data are expressed as the mean±standard deviation or the median value (quartile).
* Shows the median value (quartile).
eGFR – estimated glomerular filtration rate; HCV – hepatitis C virus; LDLT – living donor liver transplantation; MELD – model for end-stage liver disease.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358