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09 February 2021 : Original article  

Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation

Kumiko Muta1ABCDEF*, Mineaki Kitamura1ABCDE, Masaaki Hidaka2BE, Yuki Ota1AB, Takanobu Hara2BE, Akihiko Soyama2BD, Satoshi Miuma3BE, Hisamitsu Miyaaki3BE, Kazuhiko Nakao3BE, Susumu Eguchi2BDE, Hiroshi Mukae4DE, Tomoya Nishino1ADE

DOI: 10.12659/AOT.928858

Ann Transplant 2021; 26:e928858

Table 3 Univariate logistic regression analysis for elevated eGFR 1 year after living donor liver transplantation.

Odds ratio95% CIp Value
Age (yeas old)1.00 (per 1 year old)0.97–1.00.95
Male0.58 (vs Female)0.32–1.060.78
HCV antibody positive1.21 (vs negative)0.65–2.240.55
Pretransplant diabetes mellitus1.20 (vs no diabetes mellitus)0.59–2.430.62
Pretransplant hypertension1.02 (vs no hypertension)0.45–2.350.96
Pretransplant diuretics2.45 (vs no diuretics)1.26–4.760.008
Pretransplant hemoglobin0.81 (per 1 mg/dL)0.70–0.940.005
Pretransplant albumin0.69 (per 1 g/dL)0.41–1.170.17
Pretransplant eGFR0.94 (per 1ml/min/1.73 m)0.92–0.95
Pretransplant urine test abnormalities0.91 (vs no abnormalities)0.30–2.750.87
Trough value of TAC 1 year after LDLT0.82 (per 1 ng/mL)0.71–0.950.01
Trough value of TAC 1 year after LDLT2.11 (vs ≥5 ng/mL)1.04–4.280.04
Posttransplant use of TAC +Mycophenolate mofetil1.97 (vs no use)0.98–3.990.06
95% CI – 95% confidence interval; eGFR – estimated glomerular filtration rate; HCV – hepatitis C virus; LDLT – living donor liver transplantation; TAC – tacrolimus.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358