09 February 2021 : Original article
Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation
Kumiko Muta1ABCDEF*, Mineaki Kitamura1ABCDE, Masaaki Hidaka2BE, Yuki Ota1AB, Takanobu Hara2BE, Akihiko Soyama2BD, Satoshi Miuma3BE, Hisamitsu Miyaaki3BE, Kazuhiko Nakao3BE, Susumu Eguchi2BDE, Hiroshi Mukae4DE, Tomoya Nishino1ADEDOI: 10.12659/AOT.928858
Ann Transplant 2021; 26:e928858
Supplementary Table 1 Univariate logistic regression analysis for elevated eGFR 1 year after living donor liver transplantation in patients who were not administered with cyclosporine.
| Odds ratio | 95% CI | p Value | |
|---|---|---|---|
| Age (yeas old) | 1.00 (per 1 year old) | 0.97–1.02 | 0.95 |
| Male | 0.54 (vs Female) | 0.29–1.01 | 0.05 |
| HCV antibody positive | 1.37 (vs negative) | 0.71–2.63 | 0.34 |
| Pretransplant diabetes mellitus | 1.25 (vs no diabetes mellitus) | 0.60–2.61 | 0.56 |
| Pretransplant hypertension | 1.09 (vs no hypertension) | 0.46–2.54 | 0.85 |
| Pretransplant diuretics | 2.36 (vs no diuretics) | 1.20–4.66 | 0.01 |
| Pretransplant hemoglobin | 0.80 (per 1 mg/dL) | 0.69–0.93 | 0.004 |
| Pretransplant albumin | 0.73 (per 1 g/dL) | 0.43–1.24 | 0.25 |
| Pretransplant eGFR | 0.93 (per 1ml/min/1.73 m) | 0.91–0.95 | |
| Pretransplant urine test abnormalities | 1.62 (vs no abnormalities) | 0.79–3.33 | 0.19 |
| Trough value of TAC 1 year after LDLT | 0.82 (per 1 ng/mL) | 0.71–0.96 | 0.01 |
| Trough value of TAC 1 year after LDLT | 2.05 (vs ≥5 ng/mL) | 1.00–4.16 | 0.05 |
| Posttransplant use of TAC +Mycophenolate mofetil | 1.97 (vs no use) | 0.98–3.99 | 0.06 |
| 95% CI – 95% confidence interval; eGFR – estimated glomerular filtration rate; HCV – hepatitis C virus; LDLT – living donor liver transplantation; TAC – tacrolimus. | |||