Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation

Kumiko Muta; Mineaki Kitamura; Masaaki Hidaka; Yuki Ota; Takanobu Hara; Akihiko Soyama; Satoshi Miuma; Hisamitsu Miyaaki; Kazuhiko Nakao; Susumu Eguchi; Hiroshi Mukae; Tomoya Nishino

doi:10.12659/AOT.928858

09 February 2021 : Original article

Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation

Kumiko Muta^1ABCDEF*, Mineaki Kitamura^1ABCDE, Masaaki Hidaka^2BE, Yuki Ota^1AB, Takanobu Hara^2BE, Akihiko Soyama^2BD, Satoshi Miuma^3BE, Hisamitsu Miyaaki^3BE, Kazuhiko Nakao^3BE, Susumu Eguchi^2BDE, Hiroshi Mukae^4DE, Tomoya Nishino^1ADE

DOI: 10.12659/AOT.928858

Ann Transplant 2021; 26:e928858

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Supplementary Table 2 Multivariate logistic regression analysis for elevated eGFR 1 year after living donor liver transplantation in patients who were not administered with cyclosporine.

<Model 1>	Odds ratio	95% CI	p Value
Pretransplant diuretics	0.60	0.18–2.02	0.41
Pretransplant hemoglobin	0.98	0.77–1.26	0.90
Pretransplant albumin	0.82	0.36–1.88	0.64
Pretransplant eGFR	0.92	0.89–0.95
Trough value of TAC 1 year after LDLT	0.97	0.79–1.18	0.76
Posttransplant use of TAC+Mycophenolate mofetil	1.36	0.47–3.94	0.57

Pretransplant diuretics	2.52	1.02–6.22	0.045
Pretransplant hemoglobin	0.88	0.72–1.07	0.21
Pretransplant albumin	1.13	0.58–2.21	0.72
Trough value of TAC 1 year after LDLT	0.85	0.72–1.00	0.05
Posttransplant use of TAC+Mycophenolate mofetil	1.67	0.73–3.81	0.22
95% CI – 95% confidence interval; eGFR – estimated glomerular filtration rate; LDLT – living donor liver transplantation; TAC – tacrolimus.

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Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation

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