28 May 2021 : Original article
Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience
Suk Kyun Hong1ABCDEF, Nam-Joon Yi1ABCDEF*, Kwangpyo Hong1BE, Eui Soo Han1BE, Jeong-Moo Lee1BE, YoungRok Choi1BE, Kwang-Woong Lee1BE, Kyung-Suk Suh1BEDOI: 10.12659/AOT.929145
Ann Transplant 2021; 26:e929145
Table 1 Demographic and clinical characteristics of pediatric patients and their donors.
| Variables | N=255 |
|---|---|
| Sex, Male: Female | 116:139 |
| Age, mean±SD, months | 59.8±61.9 |
| Height, mean±SD, cm | 97.7±37.0 |
| Body weight, mean±SD, kg | 19.2±16.0 |
| Period of LT, n (%) | |
| Early (1988–2007) | 124 (48.6) |
| Middle (2008–2011) | 54 (21.2) |
| Recent (2012–2018) | 77 (30.2) |
| Type of LT, n (%) | |
| LDLT | 164 (64.3) |
| Whole-liver DDLT | 53 (20.8) |
| Split DDLT | 38 (14.9) |
| Underlying liver disease, n (%) | |
| Chronic liver disease | 198 (77.6) |
| Biliary atresia | 142 (55.7) |
| Wilson disease | 12 (4.7) |
| Alagille syndrome | 9 (3.5) |
| PBC or PSC | 8 (3.1) |
| Byler disease | 6 (2.4) |
| Congenital hepatic fibrosis | 6 (2.4) |
| Caroli’s disease | 4 (1.6) |
| Cholestatic hepatitis | 4 (1.6) |
| Langerhans cell histiocytosis | 2 (0.8) |
| Hemochromatosis | 2 (0.8) |
| Unknown origin liver cirrhosis | 1 (0.4) |
| Autoimmune hepatitis | 1 (0.4) |
| Cryptococcal infection related liver cirrhosis | 1 (0.4) |
| Without chronic liver disease | 57 (22.4) |
| Fulminant liver failure | 29 (11.4) |
| Glycogen storage disease | 10 (3.9) |
| Hepatoblastoma | 6 (2.4) |
| Primary hyperoxaluria | 5 (2.0) |
| Factor H deficiency | 3 (1.2) |
| Tyrosinemia type 1 | 1 (0.4) |
| Urea cycle defect | 1 (0.4) |
| Immature teratoma | 1 (0.4) |
| Chemotherapy for osteosarcoma related liver damage | 1 (0.4) |
| ABO-incompatible, n (%) | 6 (2.4) |
| Child-Pugh score, mean±SD | 8.2±2.1 |
| PELD score, mean±SD | 13.0±13.4 |
| Donor sex, Male: Female | 139:116 |
| Donor age, mean±SD, years | 28.9±12.2 |
| Donor body weight, mean±SD, kg | 60.8±16.9 |
| Relationship to recipient | |
| Mother | 79 (31.0) |
| Father | 64 (25.1) |
| Other relatives | 16 (6.3) |
| Non-relatives | 96 (37.6) |
| SD – standard deviation; LT – liver transplantation; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; PBC – primary biliary cirrhosis; PSC – primary sclerosing cholangitis; PELD – pediatric end-stage liver disease. | |