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28 May 2021: Original Paper

Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

Suk Kyun Hong ABCDEF , Nam-Joon Yi ABCDEF* , Kwangpyo Hong BE , Eui Soo Han BE , Jeong-Moo Lee BE , YoungRok Choi BE , Kwang-Woong Lee BE , Kyung-Suk Suh BE

DOI: 10.12659/AOT.929145

Ann Transplant 2021; 26:e929145

Table 1 Demographic and clinical characteristics of pediatric patients and their donors.

VariablesN=255
Sex, Male: Female116:139
Age, mean±SD, months59.8±61.9
Height, mean±SD, cm97.7±37.0
Body weight, mean±SD, kg19.2±16.0
Period of LT, n (%)
 Early (1988–2007)124 (48.6)
 Middle (2008–2011)54 (21.2)
 Recent (2012–2018)77 (30.2)
Type of LT, n (%)
 LDLT164 (64.3)
 Whole-liver DDLT53 (20.8)
 Split DDLT38 (14.9)
Underlying liver disease, n (%)
 Chronic liver disease198 (77.6)
  Biliary atresia142 (55.7)
  Wilson disease12 (4.7)
  Alagille syndrome9 (3.5)
  PBC or PSC8 (3.1)
  Byler disease6 (2.4)
 Congenital hepatic fibrosis6 (2.4)
  Caroli’s disease4 (1.6)
  Cholestatic hepatitis4 (1.6)
  Langerhans cell histiocytosis2 (0.8)
  Hemochromatosis2 (0.8)
  Unknown origin liver cirrhosis1 (0.4)
  Autoimmune hepatitis1 (0.4)
  Cryptococcal infection related liver cirrhosis1 (0.4)
 Without chronic liver disease57 (22.4)
  Fulminant liver failure29 (11.4)
  Glycogen storage disease10 (3.9)
  Hepatoblastoma6 (2.4)
  Primary hyperoxaluria5 (2.0)
  Factor H deficiency3 (1.2)
  Tyrosinemia type 11 (0.4)
  Urea cycle defect1 (0.4)
  Immature teratoma1 (0.4)
  Chemotherapy for osteosarcoma related liver damage1 (0.4)
ABO-incompatible, n (%)6 (2.4)
Child-Pugh score, mean±SD8.2±2.1
PELD score, mean±SD13.0±13.4
Donor sex, Male: Female139:116
Donor age, mean±SD, years28.9±12.2
Donor body weight, mean±SD, kg60.8±16.9
Relationship to recipient
 Mother79 (31.0)
 Father64 (25.1)
 Other relatives16 (6.3)
 Non-relatives96 (37.6)
SD – standard deviation; LT – liver transplantation; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; PBC – primary biliary cirrhosis; PSC – primary sclerosing cholangitis; PELD – pediatric end-stage liver disease.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358