28 May 2021>: Original Paper
Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience
Suk Kyun Hong ABCDEF , Nam-Joon Yi ABCDEF* , Kwangpyo Hong BE , Eui Soo Han BE , Jeong-Moo Lee BE , YoungRok Choi BE , Kwang-Woong Lee BE , Kyung-Suk Suh BEDOI: 10.12659/AOT.929145
Ann Transplant 2021; 26:e929145
Table 1 Demographic and clinical characteristics of pediatric patients and their donors.
Variables | N=255 |
---|---|
Sex, Male: Female | 116:139 |
Age, mean±SD, months | 59.8±61.9 |
Height, mean±SD, cm | 97.7±37.0 |
Body weight, mean±SD, kg | 19.2±16.0 |
Period of LT, n (%) | |
Early (1988–2007) | 124 (48.6) |
Middle (2008–2011) | 54 (21.2) |
Recent (2012–2018) | 77 (30.2) |
Type of LT, n (%) | |
LDLT | 164 (64.3) |
Whole-liver DDLT | 53 (20.8) |
Split DDLT | 38 (14.9) |
Underlying liver disease, n (%) | |
Chronic liver disease | 198 (77.6) |
Biliary atresia | 142 (55.7) |
Wilson disease | 12 (4.7) |
Alagille syndrome | 9 (3.5) |
PBC or PSC | 8 (3.1) |
Byler disease | 6 (2.4) |
Congenital hepatic fibrosis | 6 (2.4) |
Caroli’s disease | 4 (1.6) |
Cholestatic hepatitis | 4 (1.6) |
Langerhans cell histiocytosis | 2 (0.8) |
Hemochromatosis | 2 (0.8) |
Unknown origin liver cirrhosis | 1 (0.4) |
Autoimmune hepatitis | 1 (0.4) |
Cryptococcal infection related liver cirrhosis | 1 (0.4) |
Without chronic liver disease | 57 (22.4) |
Fulminant liver failure | 29 (11.4) |
Glycogen storage disease | 10 (3.9) |
Hepatoblastoma | 6 (2.4) |
Primary hyperoxaluria | 5 (2.0) |
Factor H deficiency | 3 (1.2) |
Tyrosinemia type 1 | 1 (0.4) |
Urea cycle defect | 1 (0.4) |
Immature teratoma | 1 (0.4) |
Chemotherapy for osteosarcoma related liver damage | 1 (0.4) |
ABO-incompatible, n (%) | 6 (2.4) |
Child-Pugh score, mean±SD | 8.2±2.1 |
PELD score, mean±SD | 13.0±13.4 |
Donor sex, Male: Female | 139:116 |
Donor age, mean±SD, years | 28.9±12.2 |
Donor body weight, mean±SD, kg | 60.8±16.9 |
Relationship to recipient | |
Mother | 79 (31.0) |
Father | 64 (25.1) |
Other relatives | 16 (6.3) |
Non-relatives | 96 (37.6) |
SD – standard deviation; LT – liver transplantation; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; PBC – primary biliary cirrhosis; PSC – primary sclerosing cholangitis; PELD – pediatric end-stage liver disease. |