28 May 2021>: Original Paper
Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience
Suk Kyun Hong ABCDEF , Nam-Joon Yi ABCDEF* , Kwangpyo Hong BE , Eui Soo Han BE , Jeong-Moo Lee BE , YoungRok Choi BE , Kwang-Woong Lee BE , Kyung-Suk Suh BEDOI: 10.12659/AOT.929145
Ann Transplant 2021; 26:e929145
Table 3 Univariate and multivariate analysis of factors associated with patient survival.
Variables | n | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|---|
1-year survival rate (%) | 5-year survival rate (%) | 10-year survival rate (%) | P value | HR | 95% CI | P value | ||
Sex | 0.776 | |||||||
Male | 116 | 90.5 | 88.6 | 88.6 | ||||
Female | 139 | 90.6 | 88.3 | 87.1 | ||||
Age, year | 0.491 | |||||||
72 | 87.4 | 85.8 | 85.8 | |||||
≥1 | 183 | 91.8 | 89.4 | 88.6 | ||||
Body weight, kg | 0.025 | |||||||
14 | 69.6 | 69.6 | 69.6 | 2.78 | 0.74–10.36 | 0.130 | ||
≥6 | 241 | 91.7 | 89.5 | 88.8 | Reference | |||
Period of LT | 0.274 | |||||||
Early (1988–2007) | 124 | 87.0 | 85.4 | 84.6 | ||||
Middle (2008–2011) | 54 | 94.4 | 90.7 | 90.7 | ||||
Recent (2012–2018) | 77 | 93.4 | 91.9 | – | ||||
Type of LT | 0.029 | |||||||
LDLT | 164 | 93.8 | 91.9 | 91.1 | Reference | |||
Whole-liver DDLT | 53 | 79.2 | 79.2 | 79.2 | 1.55 | 0.47–5.15 | 0.471 | |
Split DDLT | 38 | 92.1 | 86.4 | 86.4 | 1.70 | 0.53–5.47 | 0.372 | |
Underlying disease | ||||||||
BA vs others | 0.058 | |||||||
BA | 142 | 93.6 | 92.1 | 91.1 | ||||
Others | 113 | 86.7 | 83.8 | 83.8 | ||||
Fulminant vs others | 0.015 | |||||||
Fulminant | 29 | 75.7 | 75.7 | 75.7 | 1.73 | 0.39–7.57 | 0.469 | |
Others | 226 | 92.4 | 90.1 | 89.4 | Reference | |||
Chronic liver disease vs others | 0.011 | |||||||
Chronic liver disease | 198 | 92.9 | 91.3 | 90.5 | Reference | |||
Others | 57 | 82.3 | 78.5 | 78.5 | 2.69 | 1.14–6.38 | 0.024 | |
PELD score | 0.005 | |||||||
214 | 94.8 | 92.8 | 92.1 | Reference | ||||
≥30 | 25 | 76.0 | 76.0 | 76.0 | 2.81 | 1.07–7.37 | 0.036 | |
Child-Pugh score | 0.898 | |||||||
A | 45 | 95.6 | 90.8 | 90.8 | ||||
B, C | 194 | 92.2 | 91.1 | 90.3 | ||||
Postoperative complication | ||||||||
Hepatic artery | 0.024 | |||||||
Yes | 14 | 69.6 | 69.6 | 69.6 | 2.72 | 0.82–9.08 | 0.103 | |
No | 241 | 91.7 | 89.5 | 88.8 | Reference | |||
Portal vein | 0.802 | |||||||
Yes | 22 | 95.5 | 90.9 | 83.9 | ||||
No | 233 | 90.1 | 88.2 | 88.2 | ||||
Hepatic vein | 0.073 | |||||||
Yes | 24 | 100 | 100 | 100 | ||||
No | 231 | 89.6 | 87.3 | 86.6 | ||||
Bile duct | 0.720 | |||||||
Yes | 29 | 93.1 | 89.4 | 83.4 | ||||
No | 226 | 90.2 | 88.3 | 88.3 | ||||
Acute rejection | 0.179 | |||||||
Yes | 49 | 95.8 | 93.4 | 93.4 | ||||
No | 206 | 89.3 | 87.3 | 86.5 | ||||
Post-transplant lymphoproliferative disorder | 0.344 | |||||||
Yes | 19 | 100 | 94.7 | 94.7 | ||||
No | 236 | 89.8 | 88.0 | 87.3 | ||||
Donor sex | 0.777 | |||||||
Male | 139 | 90.6 | 88.2 | 87.1 | ||||
Female | 116 | 90.5 | 88.7 | 88.7 | ||||
Donor age, years | 0.280 | |||||||
44 | 84.0 | 84.0 | 84.0 | |||||
≥18 | 211 | 91.9 | 89.4 | 88.7 | ||||
Relationship to recipient | 0.067 | |||||||
Mother | 79 | 94.9 | 93.6 | 93.6 | ||||
Other than mother | 176 | 88.6 | 86.1 | 85.2 | ||||
HR – hazard ratio; CI – confidence interval; LT – liver transplantation; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; BA – biliary atresia; PELD – pediatric end-stage liver disease. |