Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

Suk Kyun Hong; Nam-Joon Yi; Kwangpyo Hong; Eui Soo Han; Jeong-Moo Lee; YoungRok Choi; Kwang-Woong Lee; Kyung-Suk Suh

doi:10.12659/AOT.929145

28 May 2021 : Original article

Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

Suk Kyun Hong^1ABCDEF, Nam-Joon Yi^1ABCDEF*, Kwangpyo Hong^1BE, Eui Soo Han^1BE, Jeong-Moo Lee^1BE, YoungRok Choi^1BE, Kwang-Woong Lee^1BE, Kyung-Suk Suh^1BE

DOI: 10.12659/AOT.929145

Ann Transplant 2021; 26:e929145

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Table 3 Univariate and multivariate analysis of factors associated with patient survival.

Variables	n	Univariate analysis				Multivariate analysis
Variables	n	1-year survival rate (%)	5-year survival rate (%)	10-year survival rate (%)	P value	HR	95% CI	P value
Sex					0.776
Male	116	90.5	88.6	88.6
Female	139	90.6	88.3	87.1
Age, year					0.491
<1	72	87.4	85.8	85.8
≥1	183	91.8	89.4	88.6
Body weight, kg					0.025
<6	14	69.6	69.6	69.6		2.78	0.74–10.36	0.130
≥6	241	91.7	89.5	88.8			Reference
Period of LT					0.274
Early (1988–2007)	124	87.0	85.4	84.6
Middle (2008–2011)	54	94.4	90.7	90.7
Recent (2012–2018)	77	93.4	91.9	–
Type of LT					0.029
LDLT	164	93.8	91.9	91.1			Reference
Whole-liver DDLT	53	79.2	79.2	79.2		1.55	0.47–5.15	0.471
Split DDLT	38	92.1	86.4	86.4		1.70	0.53–5.47	0.372
Underlying disease
BA vs others					0.058
BA	142	93.6	92.1	91.1
Others	113	86.7	83.8	83.8
Fulminant vs others					0.015
Fulminant	29	75.7	75.7	75.7		1.73	0.39–7.57	0.469
Others	226	92.4	90.1	89.4			Reference
Chronic liver disease vs others					0.011
Chronic liver disease	198	92.9	91.3	90.5			Reference
Others	57	82.3	78.5	78.5		2.69	1.14–6.38	0.024
PELD score					0.005
<30	214	94.8	92.8	92.1			Reference
≥30	25	76.0	76.0	76.0		2.81	1.07–7.37	0.036
Child-Pugh score					0.898
A	45	95.6	90.8	90.8
B, C	194	92.2	91.1	90.3
Postoperative complication
Hepatic artery					0.024
Yes	14	69.6	69.6	69.6		2.72	0.82–9.08	0.103
No	241	91.7	89.5	88.8			Reference
Portal vein					0.802
Yes	22	95.5	90.9	83.9
No	233	90.1	88.2	88.2
Hepatic vein					0.073
Yes	24	100	100	100
No	231	89.6	87.3	86.6
Bile duct					0.720
Yes	29	93.1	89.4	83.4
No	226	90.2	88.3	88.3
Acute rejection					0.179
Yes	49	95.8	93.4	93.4
No	206	89.3	87.3	86.5
Post-transplant lymphoproliferative disorder					0.344
Yes	19	100	94.7	94.7
No	236	89.8	88.0	87.3
Donor sex					0.777
Male	139	90.6	88.2	87.1
Female	116	90.5	88.7	88.7
Donor age, years					0.280
<18	44	84.0	84.0	84.0
≥18	211	91.9	89.4	88.7
Relationship to recipient					0.067
Mother	79	94.9	93.6	93.6
Other than mother	176	88.6	86.1	85.2
HR – hazard ratio; CI – confidence interval; LT – liver transplantation; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; BA – biliary atresia; PELD – pediatric end-stage liver disease.

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Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

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