Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

Suk Kyun Hong; Nam-Joon Yi; Kwangpyo Hong; Eui Soo Han; Jeong-Moo Lee; YoungRok Choi; Kwang-Woong Lee; Kyung-Suk Suh

doi:10.12659/AOT.929145

28 May 2021 : Original article

Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

Suk Kyun Hong^1ABCDEF, Nam-Joon Yi^1ABCDEF*, Kwangpyo Hong^1BE, Eui Soo Han^1BE, Jeong-Moo Lee^1BE, YoungRok Choi^1BE, Kwang-Woong Lee^1BE, Kyung-Suk Suh^1BE

DOI: 10.12659/AOT.929145

Ann Transplant 2021; 26:e929145

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Table 4 Univariate and multivariate analysis of factors associated with graft survival.

Variables	n	Univariate analysis				Multivariate analysis
Variables	n	1-year survival rate (%)	5-year survival rate (%)	10-year survival rate (%)	P value	HR	95% CI	P value
Sex					0.412
Male	116	91.2	90.2	88.8
Female	139	88.5	87.0	85.8
Age, year					0.900
<1	72	88.7	88.7	86.1
≥1	183	90.1	88.4	87.5
Body weight, kg					0.035
<6	14	71.4	71.4	71.4		2.91	1.00–8.45	0.050
≥6	241	90.8	89.5	88.1			Reference
Period of LT					0.841
Early (1988–2007)	124	87.8	86.9	86.1
Middle (2008–2011)	54	94.4	90.4	87.9
Recent (2012–2018)	77	89.6	89.6	-
Type of LT					0.043
LDLT	164	92.0	92.0	90.3			Reference
Whole-liver DDLT	53	81.0	78.9	78.9		3.93	1.71–9.03	0.001
Split DDLT	38	92.1	86.3	86.3		2.29	0.79–6.64	0.127
Underlying disease
BA vs others					0.015
BA	142	93.6	92.9	91.8		0.68	0.26–1.79	0.437
Others	113	84.8	82.9	81.3		Reference
Fulminant vs others					0.001
Fulminant	29	71.7	71.7	63.8		3.13	1.35–7.27	0.008
Others	226	92.0	90.6	89.9			Reference
Chronic liver disease vs others					0.004
Chronic liver disease	198	92.4	91.3	90.5		1.60	0.43–5.87	0.482
Others	57	80.4	78.4	74.5			Reference
PELD score					0.072
<30	214	92.5	91.5	90.7
≥30	25	83.6	83.6	75.2
Child-Pugh score					0.433
A	45	95.6	93.1	93.1
B, C	194	90.6	90.1	88.4
Postoperative complication
Hepatic artery					<0.001
Yes	14	61.9	49.5	37.1		6.10	2.42–15.36	<0.001
No	241	91.2	90.4	89.7			Reference
Portal vein					0.126
Yes	22	86.4	81.8	75.0
No	233	90.0	89.1	88.4
Hepatic vein					0.540
Yes	24	83.3	83.3	83.3
No	231	90.4	89.0	87.6
Bile duct					0.157
Yes	29	86.2	82.6	77.1
No	226	90.2	89.2	88.5
Donor sex					0.685
Male	139	89.2	87.6	86.5
Female	116	90.4	89.4	88.0
Donor age, years					0.123
<18	44	84.1	81.5	81.5
≥18	211	90.9	89.9	88.4
Relationship to recipient					0.450
Mother	79	91.1	91.1	89.1
Other than mother	176	89.1	87.2	86.3
HR – hazard ratio; CI – confidence interval; LT – liver transplantation; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; BA – biliary atresia; PELD – pediatric end-stage liver disease.

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Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience

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